Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia

BACKGROUND: Aberrant activation of Wnt signalling through hypermethylation of Wnt inhibitor genes is involved in several human malignancies, including acute myeloid leukaemia (AML). It remains unclear whether hypermethylation of Wnt inhibitors is associated with molecular gene mutations in the devel...

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Detalles Bibliográficos
Autores principales: Hou, H-A, Kuo, Y-Y, Liu, C-Y, Lee, M C, Tang, J-L, Chen, C-Y, Chou, W-C, Huang, C-F, Lee, F-Y, Liu, M-C, Yao, M, Tien, H-F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251886/
https://www.ncbi.nlm.nih.gov/pubmed/22095226
http://dx.doi.org/10.1038/bjc.2011.471

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