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PTEN and PIK3CA gene copy numbers and poor outcomes in non-small cell lung cancer patients with gefitinib therapy

BACKGROUND: Preclinical studies in non-small cell lung cancer (NSCLC) suggest the interaction of PTEN and PI3K affects sensitivity to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We investigated outcomes in relation to PTEN, PIK3CA and EGFR gene copy number, and chromos...

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Detalles Bibliográficos
Autores principales:	Fidler, M J, Morrison, L E, Basu, S, Buckingham, L, Walters, K, Batus, M, Jacobson, K K, Jewell, S S, Coon, J, Bonomi, P D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251891/ https://www.ncbi.nlm.nih.gov/pubmed/22095222 http://dx.doi.org/10.1038/bjc.2011.494

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