Notch signalling in cancer progression and bone metastasis

Classically known for its indispensible role in embryonic development, the Notch signalling pathway is gaining recognition for its regulation of adult tissue homoeostasis and aberrant activation in disease pathogenesis. The pathway has been implicated in cancer initiation and development, as well as...

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Detalles Bibliográficos
Autores principales: Sethi, N, Kang, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251892/
https://www.ncbi.nlm.nih.gov/pubmed/22075946
http://dx.doi.org/10.1038/bjc.2011.497
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author Sethi, N
Kang, Y
author_facet Sethi, N
Kang, Y
author_sort Sethi, N
collection PubMed
description Classically known for its indispensible role in embryonic development, the Notch signalling pathway is gaining recognition for its regulation of adult tissue homoeostasis and aberrant activation in disease pathogenesis. The pathway has been implicated in cancer initiation and development, as well as early stages of cancer progression by regulating conserved cellular programs such as the epithelial-to-mesenchymal transition. We recently extended the role of Notch signalling to late stages of tumour progression by elucidating a stroma-dependent mechanism for the pathway in osteolytic bone metastasis. Of clinical significance, disrupting the Notch pathway and associated molecular mediators of Notch-dependent bone metastasis may provide novel therapeutic strategies to combat aggressive bone metastatic disease.
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spelling pubmed-32518922012-12-06 Notch signalling in cancer progression and bone metastasis Sethi, N Kang, Y Br J Cancer Minireview Classically known for its indispensible role in embryonic development, the Notch signalling pathway is gaining recognition for its regulation of adult tissue homoeostasis and aberrant activation in disease pathogenesis. The pathway has been implicated in cancer initiation and development, as well as early stages of cancer progression by regulating conserved cellular programs such as the epithelial-to-mesenchymal transition. We recently extended the role of Notch signalling to late stages of tumour progression by elucidating a stroma-dependent mechanism for the pathway in osteolytic bone metastasis. Of clinical significance, disrupting the Notch pathway and associated molecular mediators of Notch-dependent bone metastasis may provide novel therapeutic strategies to combat aggressive bone metastatic disease. Nature Publishing Group 2011-12-06 2011-11-10 /pmc/articles/PMC3251892/ /pubmed/22075946 http://dx.doi.org/10.1038/bjc.2011.497 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Sethi, N
Kang, Y
Notch signalling in cancer progression and bone metastasis
title Notch signalling in cancer progression and bone metastasis
title_full Notch signalling in cancer progression and bone metastasis
title_fullStr Notch signalling in cancer progression and bone metastasis
title_full_unstemmed Notch signalling in cancer progression and bone metastasis
title_short Notch signalling in cancer progression and bone metastasis
title_sort notch signalling in cancer progression and bone metastasis
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251892/
https://www.ncbi.nlm.nih.gov/pubmed/22075946
http://dx.doi.org/10.1038/bjc.2011.497
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