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Fractalkine and Other Chemokines in Primary Biliary Cirrhosis
Primary biliary cirrhosis (PBC) is characterized by the autoimmune injury of small intrahepatic bile duct. On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251911/ https://www.ncbi.nlm.nih.gov/pubmed/22235377 http://dx.doi.org/10.1155/2012/102839 |
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author | Shimoda, Shinji Selmi, Carlo Gershwin, M. Eric |
author_facet | Shimoda, Shinji Selmi, Carlo Gershwin, M. Eric |
author_sort | Shimoda, Shinji |
collection | PubMed |
description | Primary biliary cirrhosis (PBC) is characterized by the autoimmune injury of small intrahepatic bile duct. On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion. To address this issue, we challenged BEC using multiple toll-like receptor (TLR) ligands as well as autologous liver infiltrating mononuclear cells (LMNC) with subsequent measurement of BEC phenotype and chemokine production and LMNC chemotaxis by quantifying specific chemokines, specially CX3CL1 (fractalkine). We submit the hypothesis that BEC are in fact the innocent victims of the autoimmune injury and that the adaptive immune response is critical in PBC. |
format | Online Article Text |
id | pubmed-3251911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32519112012-01-10 Fractalkine and Other Chemokines in Primary Biliary Cirrhosis Shimoda, Shinji Selmi, Carlo Gershwin, M. Eric Int J Hepatol Research Article Primary biliary cirrhosis (PBC) is characterized by the autoimmune injury of small intrahepatic bile duct. On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion. To address this issue, we challenged BEC using multiple toll-like receptor (TLR) ligands as well as autologous liver infiltrating mononuclear cells (LMNC) with subsequent measurement of BEC phenotype and chemokine production and LMNC chemotaxis by quantifying specific chemokines, specially CX3CL1 (fractalkine). We submit the hypothesis that BEC are in fact the innocent victims of the autoimmune injury and that the adaptive immune response is critical in PBC. Hindawi Publishing Corporation 2012 2011-08-09 /pmc/articles/PMC3251911/ /pubmed/22235377 http://dx.doi.org/10.1155/2012/102839 Text en Copyright © 2012 Shinji Shimoda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shimoda, Shinji Selmi, Carlo Gershwin, M. Eric Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
title | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
title_full | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
title_fullStr | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
title_full_unstemmed | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
title_short | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
title_sort | fractalkine and other chemokines in primary biliary cirrhosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251911/ https://www.ncbi.nlm.nih.gov/pubmed/22235377 http://dx.doi.org/10.1155/2012/102839 |
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