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Extrinsic and intrinsic determinants of nerve regeneration
After central nervous system (CNS) injury axons fail to regenerate often leading to persistent neurologic deficit although injured peripheral nervous system (PNS) axons mount a robust regenerative response that may lead to functional recovery. Some of the failures of CNS regeneration arise from the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251917/ https://www.ncbi.nlm.nih.gov/pubmed/22292105 http://dx.doi.org/10.1177/2041731411418392 |
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author | Ferguson, Toby A. Son, Young-Jin |
author_facet | Ferguson, Toby A. Son, Young-Jin |
author_sort | Ferguson, Toby A. |
collection | PubMed |
description | After central nervous system (CNS) injury axons fail to regenerate often leading to persistent neurologic deficit although injured peripheral nervous system (PNS) axons mount a robust regenerative response that may lead to functional recovery. Some of the failures of CNS regeneration arise from the many glial-based inhibitory molecules found in the injured CNS, whereas the intrinsic regenerative potential of some CNS neurons is actively curtailed during CNS maturation and limited after injury. In this review, the molecular basis for extrinsic and intrinsic modulation of axon regeneration within the nervous system is evaluated. A more complete understanding of the factors limiting axonal regeneration will provide a rational basis, which is used to develop improved treatments for nervous system injury. |
format | Online Article Text |
id | pubmed-3251917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-32519172012-01-30 Extrinsic and intrinsic determinants of nerve regeneration Ferguson, Toby A. Son, Young-Jin J Tissue Eng Article After central nervous system (CNS) injury axons fail to regenerate often leading to persistent neurologic deficit although injured peripheral nervous system (PNS) axons mount a robust regenerative response that may lead to functional recovery. Some of the failures of CNS regeneration arise from the many glial-based inhibitory molecules found in the injured CNS, whereas the intrinsic regenerative potential of some CNS neurons is actively curtailed during CNS maturation and limited after injury. In this review, the molecular basis for extrinsic and intrinsic modulation of axon regeneration within the nervous system is evaluated. A more complete understanding of the factors limiting axonal regeneration will provide a rational basis, which is used to develop improved treatments for nervous system injury. SAGE Publications 2011-09-13 /pmc/articles/PMC3251917/ /pubmed/22292105 http://dx.doi.org/10.1177/2041731411418392 Text en © SAGE Publications 2011 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Ferguson, Toby A. Son, Young-Jin Extrinsic and intrinsic determinants of nerve regeneration |
title | Extrinsic and intrinsic determinants of nerve regeneration |
title_full | Extrinsic and intrinsic determinants of nerve regeneration |
title_fullStr | Extrinsic and intrinsic determinants of nerve regeneration |
title_full_unstemmed | Extrinsic and intrinsic determinants of nerve regeneration |
title_short | Extrinsic and intrinsic determinants of nerve regeneration |
title_sort | extrinsic and intrinsic determinants of nerve regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251917/ https://www.ncbi.nlm.nih.gov/pubmed/22292105 http://dx.doi.org/10.1177/2041731411418392 |
work_keys_str_mv | AT fergusontobya extrinsicandintrinsicdeterminantsofnerveregeneration AT sonyoungjin extrinsicandintrinsicdeterminantsofnerveregeneration |