Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients

Pro-coagulant and pro-inflammatory intramyocardial (micro)vasculature plays an important role in acute myocardial infarction (AMI). Currently, inhibition of serine protease dipeptidyl peptidase 4 (DPP4) receives a lot of interest as an anti-hyperglycemic therapy in type 2 diabetes patients. However,...

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Detalles Bibliográficos
Autores principales: Krijnen, Paul A. J., Hahn, Nynke E., Kholová, Ivana, Baylan, Umit, Sipkens, Jessica A., van Alphen, Floris P., Vonk, Alexander B. A., Simsek, Suat, Meischl, Christof, Schalkwijk, Casper G., van Buul, Jaap D., van Hinsbergh, Victor W. M., Niessen, Hans W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252036/
https://www.ncbi.nlm.nih.gov/pubmed/22167343
http://dx.doi.org/10.1007/s00395-011-0233-5

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