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SIRT1 associates with eIF2-alpha and regulates the cellular stress response
SIRT1 is a NAD+ dependent protein deacetylase known to increase longevity in model organisms. SIRT1 regulates cellular response to oxidative and/or genotoxic stress by regulating proteins such as p53 and FOXO. The eukaryotic initiation factor-2, eIF2, plays a critical role in the integrated stress r...
Autores principales: | Ghosh, Hiyaa Singhee, Reizis, Boris, Robbins, Paul D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252071/ https://www.ncbi.nlm.nih.gov/pubmed/22355666 http://dx.doi.org/10.1038/srep00150 |
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