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The Effect of Finasteride and Dutasteride on the Growth of WPE1-NA22 Prostate Cancer Xenografts in Nude Mice

BACKGROUND: 5α-reductase 1 (5αR1) and 5α-reductase 2 (5αR2) convert testosterone into the more potent androgen dihydrotestosterone. 5αR2 is the main isoenzyme in normal prostate tissue; however, most prostate tumors have increased 5αR1 and decreased 5αR2 expression. Previously, finasteride (5αR2 inh...

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Detalles Bibliográficos
Autores principales:	Opoku-Acheampong, Alexander B., Nelsen, Michelle K., Unis, Dave, Lindshield, Brian L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252297/ https://www.ncbi.nlm.nih.gov/pubmed/22242155 http://dx.doi.org/10.1371/journal.pone.0029068

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