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Poly(ADP-Ribose) Polymerase 1 (PARP-1) Regulates Ribosomal Biogenesis in Drosophila Nucleoli

Poly(ADP-ribose) polymerase 1 (PARP1), a nuclear protein, utilizes NAD to synthesize poly(AD-Pribose) (pADPr), resulting in both automodification and the modification of acceptor proteins. Substantial amounts of PARP1 and pADPr (up to 50%) are localized to the nucleolus, a subnuclear organelle known...

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Detalles Bibliográficos
Autores principales:	Boamah, Ernest K., Kotova, Elena, Garabedian, Mikael, Jarnik, Michael, Tulin, Alexei V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252306/ https://www.ncbi.nlm.nih.gov/pubmed/22242017 http://dx.doi.org/10.1371/journal.pgen.1002442

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