Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin

BACKGROUND: Botulinum neurotoxin A (BoNT/A), mainly represented by subtype A1, is the most toxic substance known. It causes naturally-occurring food poisoning, and is among the biological agents at the highest risk of being weaponized. Several antibodies neutralizing BoNT/A by targeting its heavy ch...

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Detalles Bibliográficos
Autores principales: Chahboun, Siham, Hust, Michael, Liu, Yvonne, Pelat, Thibaut, Miethe, Sebastian, Helmsing, Saskia, Jones, Russell GA, Sesardic, Dorothea, Thullier, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252318/
https://www.ncbi.nlm.nih.gov/pubmed/22111995
http://dx.doi.org/10.1186/1472-6750-11-113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252318/
https://www.ncbi.nlm.nih.gov/pubmed/22111995
http://dx.doi.org/10.1186/1472-6750-11-113

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