Therapeutic Targeting of STAT3 (Signal Transducers and Activators of Transcription 3) Pathway Inhibits Experimental Autoimmune Uveitis

Mice with targeted deletion of STAT3 in CD4(+) T-cells do not develop experimental autoimmune uveitis (EAU) or experimental autoimmune encephalomyelitis (EAE), in part, because they cannot generate pathogenic Th17 cells. In this study, we have used ORLL-NIH001, a small synthetic compound that inhibi...

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Detalles Bibliográficos
Autores principales: Yu, Cheng-Rong, Lee, Yun Sang, Mahdi, Rashid M., Surendran, Narayanan, Egwuagu, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252323/
https://www.ncbi.nlm.nih.gov/pubmed/22238646
http://dx.doi.org/10.1371/journal.pone.0029742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252323/
https://www.ncbi.nlm.nih.gov/pubmed/22238646
http://dx.doi.org/10.1371/journal.pone.0029742

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