Cargando…

Conformational Altered p53 as an Early Marker of Oxidative Stress in Alzheimer's Disease

In order to study oxidative stress in peripheral cells of Alzheimer's disease (AD) patients, immortalized lymphocytes derived from two peculiar cohorts of patients, referring to early onset AD (EOSAD) and subjects harboured AD related mutation (ADmut), were used. Oxidative stress was evaluated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buizza, Laura, Cenini, Giovanna, Lanni, Cristina, Ferrari-Toninelli, Giulia, Prandelli, Chiara, Govoni, Stefano, Buoso, Erica, Racchi, Marco, Barcikowska, Maria, Styczynska, Maria, Szybinska, Aleksandra, Butterfield, David Allan, Memo, Maurizio, Uberti, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252333/ https://www.ncbi.nlm.nih.gov/pubmed/22242180 http://dx.doi.org/10.1371/journal.pone.0029789

Ejemplares similares

Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression
por: Buizza, L, et al.
Publicado: (2013)

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease
por: Cenini, Giovanna, et al.
Publicado: (2008)

Homeodomain Interacting Protein Kinase 2: A Target for Alzheimer's Beta Amyloid Leading to Misfolded p53 and Inappropriate Cell Survival
por: Lanni, Cristina, et al.
Publicado: (2010)

Notch ligand Delta-like 1 as a novel molecular target in childhood neuroblastoma
por: Bettinsoli, P., et al.
Publicado: (2017)

Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole
por: Ferrari-Toninelli, Giulia, et al.
Publicado: (2010)

Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
por: Stanga, Serena, et al.
Publicado: (2010)

Mitochondrial Alterations in Peripheral Mononuclear Blood Cells from Alzheimer's Disease and Mild Cognitive Impairment Patients
por: Delbarba, A., et al.
Publicado: (2016)

Alzheimer's disease: new diagnostic and therapeutic tools
por: Racchi, Marco, et al.
Publicado: (2008)

Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders
por: Bonini, Sara Anna, et al.
Publicado: (2017)

Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights from Proteomics into Important Pathways Regulated by p53
por: Fiorini, Ada, et al.
Publicado: (2012)

Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence
por: Racchi, Marco, et al.
Publicado: (2017)

Endocrine-Disrupting Chemicals’ (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1
por: Buoso, Erica, et al.
Publicado: (2020)

A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages
por: Abate, Giulia, et al.
Publicado: (2020)

P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?
por: Szybińska, Aleksandra, et al.
Publicado: (2017)

The pleiotropic role of p53 in functional/dysfunctional neurons: focus on pathogenesis and diagnosis of Alzheimer’s disease
por: Abate, Giulia, et al.
Publicado: (2020)

Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers
por: Masi, Mirco, et al.
Publicado: (2021)

γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice
por: Rungratanawanich, Wiramon, et al.
Publicado: (2019)

Radiological Evaluation of Strategic Structures in Patients with Mild Cognitive Impairment and Early Alzheimer’s Disease
por: Nesteruk, Tomasz, et al.
Publicado: (2016)

Redox Homeostasis and Natural Dietary Compounds: Focusing on Antioxidants of Rice (Oryza sativa L.)
por: Rungratanawanich, Wiramon, et al.
Publicado: (2018)

Impact of COVID-19 on Alzheimer’s Disease Risk: Viewpoint for Research Action
por: Abate, Giulia, et al.
Publicado: (2020)

The Labyrinthine Landscape of APP Processing: State of the Art and Possible Novel Soluble APP-Related Molecular Players in Traumatic Brain Injury and Neurodegeneration
por: Masi, Mirco, et al.
Publicado: (2023)

Favorable prognostic role of tropomodulins in neuroblastoma
por: Bettinsoli, Paola, et al.
Publicado: (2018)

Targeting dementias through cancer kinases inhibition
por: Fagiani, Francesca, et al.
Publicado: (2020)

(Dys)regulation of Synaptic Activity and Neurotransmitter Release by β-Amyloid: A Look Beyond Alzheimer's Disease Pathogenesis
por: Fagiani, Francesca, et al.
Publicado: (2021)

The Peptidyl-prolyl Isomerase Pin1 in Neuronal Signaling: from Neurodevelopment to Neurodegeneration
por: Fagiani, Francesca, et al.
Publicado: (2020)

Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds
por: Fagiani, Francesca, et al.
Publicado: (2020)

Proteostasis Deregulation in Neurodegeneration and Its Link with Stress Granules: Focus on the Scaffold and Ribosomal Protein RACK1
por: Masi, Mirco, et al.
Publicado: (2022)

Electrochemical detection of different p53 conformations by using nanostructured surfaces
por: Tonello, Sarah, et al.
Publicado: (2019)

Nutrition and AGE-ing: Focusing on Alzheimer's Disease
por: Abate, Giulia, et al.
Publicado: (2017)

Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells
por: Buoso, Erica, et al.
Publicado: (2021)

Cortical Structure Alterations and Social Behavior Impairment in p50-Deficient Mice
por: Bonini, Sara Anna, et al.
Publicado: (2016)

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2
por: Catanzaro, Michele, et al.
Publicado: (2020)

OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression
por: Masi, Mirco, et al.
Publicado: (2020)

PIN1 gene variants in Alzheimer's disease
por: Maruszak, Aleksandra, et al.
Publicado: (2009)

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update
por: Cenini, Giovanna, et al.
Publicado: (2019)

The coupling of RACK1 with the beta isoform of the glucocorticoid receptor promotes resilience to chronic stress exposure
por: Brivio, Paola, et al.
Publicado: (2021)

Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway
por: Rungratanawanich, W., et al.
Publicado: (2018)

Immune and Nervous Systems Interaction in Endocrine Disruptors Toxicity: The Case of Atrazine
por: Galbiati, Valentina, et al.
Publicado: (2021)

Pin1 as Molecular Switch in Vascular Endothelium: Notes on Its Putative Role in Age-Associated Vascular Diseases
por: Fagiani, Francesca, et al.
Publicado: (2021)

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View
por: Cenini, Giovanna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kvb2g63suppfbqr4apv0r26m02