Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of Inhibitors

Trans-sialidase (TS), a virulence factor from Trypanosoma cruzi, is an enzyme playing key roles in the biology of this protozoan parasite. Absent from the mammalian host, it constitutes a potential target for the development of novel chemotherapeutic drugs, an urgent need to combat Chagas' dise...

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Detalles Bibliográficos
Autores principales: Buschiazzo, Alejandro, Muiá, Romina, Larrieux, Nicole, Pitcovsky, Tamara, Mucci, Juan, Campetella, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252381/
https://www.ncbi.nlm.nih.gov/pubmed/22241998
http://dx.doi.org/10.1371/journal.ppat.1002474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252381/
https://www.ncbi.nlm.nih.gov/pubmed/22241998
http://dx.doi.org/10.1371/journal.ppat.1002474

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