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Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse knees

OBJECTIVE: To investigate the effects of lubricin gene dosage and cyclic loading on whole joint coefficient of friction and articular cartilage surface integrity in mouse knee joints. METHODS: Joints from mice with 2 (Prg4(+/+)), 1 (Prg4(+/−)), or no (Prg4(−/−)) functioning lubricin alleles were sub...

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Detalles Bibliográficos
Autores principales:	Drewniak, Elizabeth I, Jay, Gregory D, Fleming, Braden C, Zhang, Ling, Warman, Matthew L, Crisco, Joseph J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:	Osteoarthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252402/ https://www.ncbi.nlm.nih.gov/pubmed/21905020 http://dx.doi.org/10.1002/art.33337

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