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Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial
OBJECTIVES: Mycoplasma genitalium and Chlamydia trachomatis are the primary pathogens detected from non-gonococcal urethritis (NGU). In this study, the efficacy of gatifloxacin was examined against M genitalium-related urethritis. METHODS: The study was an open clinical trial evaluating the effectiv...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252599/ https://www.ncbi.nlm.nih.gov/pubmed/21531704 http://dx.doi.org/10.1136/sti.2010.048553 |
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author | Hamasuna, Ryoichi Takahashi, Satoshi Kiyota, Hiroshi Yasuda, Mitsuru Hayami, Hiroshi Arakawa, Soichi Tomono, Kazunori Matsumoto, Tetsuro |
author_facet | Hamasuna, Ryoichi Takahashi, Satoshi Kiyota, Hiroshi Yasuda, Mitsuru Hayami, Hiroshi Arakawa, Soichi Tomono, Kazunori Matsumoto, Tetsuro |
author_sort | Hamasuna, Ryoichi |
collection | PubMed |
description | OBJECTIVES: Mycoplasma genitalium and Chlamydia trachomatis are the primary pathogens detected from non-gonococcal urethritis (NGU). In this study, the efficacy of gatifloxacin was examined against M genitalium-related urethritis. METHODS: The study was an open clinical trial evaluating the effectiveness of gatifloxacin with 200 mg doses twice a day for 7 days against male NGU. RESULTS: Between March and September 2008, 169 male patients were enrolled, and microbiological and clinical cure rates could be evaluated in 86 patients detected with C trachomatis or M genitalium and in 135 with NGU, respectively. Microbiological cure rates of gatifloxacin against C trachomatis and M genitalium were 100% and 83%, respectively, and the total clinical cure rate was 99%. CONCLUSION: Analysis of in-vivo and in-vitro data from the literature of fluoroquinolone efficacies against M genitalium suggests that a MIC90 of 0.125 μg/ml or less may be useful for optimal activity against M genitalium infection. |
format | Online Article Text |
id | pubmed-3252599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BMJ Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-32525992012-01-17 Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial Hamasuna, Ryoichi Takahashi, Satoshi Kiyota, Hiroshi Yasuda, Mitsuru Hayami, Hiroshi Arakawa, Soichi Tomono, Kazunori Matsumoto, Tetsuro Sex Transm Infect Clinical OBJECTIVES: Mycoplasma genitalium and Chlamydia trachomatis are the primary pathogens detected from non-gonococcal urethritis (NGU). In this study, the efficacy of gatifloxacin was examined against M genitalium-related urethritis. METHODS: The study was an open clinical trial evaluating the effectiveness of gatifloxacin with 200 mg doses twice a day for 7 days against male NGU. RESULTS: Between March and September 2008, 169 male patients were enrolled, and microbiological and clinical cure rates could be evaluated in 86 patients detected with C trachomatis or M genitalium and in 135 with NGU, respectively. Microbiological cure rates of gatifloxacin against C trachomatis and M genitalium were 100% and 83%, respectively, and the total clinical cure rate was 99%. CONCLUSION: Analysis of in-vivo and in-vitro data from the literature of fluoroquinolone efficacies against M genitalium suggests that a MIC90 of 0.125 μg/ml or less may be useful for optimal activity against M genitalium infection. BMJ Group 2011-04-28 2011-08 /pmc/articles/PMC3252599/ /pubmed/21531704 http://dx.doi.org/10.1136/sti.2010.048553 Text en © 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. |
spellingShingle | Clinical Hamasuna, Ryoichi Takahashi, Satoshi Kiyota, Hiroshi Yasuda, Mitsuru Hayami, Hiroshi Arakawa, Soichi Tomono, Kazunori Matsumoto, Tetsuro Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial |
title | Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial |
title_full | Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial |
title_fullStr | Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial |
title_full_unstemmed | Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial |
title_short | Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial |
title_sort | effect of gatifloxacin against mycoplasma genitalium-related urethritis: an open clinical trial |
topic | Clinical |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252599/ https://www.ncbi.nlm.nih.gov/pubmed/21531704 http://dx.doi.org/10.1136/sti.2010.048553 |
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