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Nanomedicine as an emerging approach against intracellular pathogens
Diseases such as tuberculosis, hepatitis, and HIV/AIDS are caused by intracellular pathogens and are a major burden to the global medical community. Conventional treatments for these diseases typically consist of long-term therapy with a combination of drugs, which may lead to side effects and contr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252676/ https://www.ncbi.nlm.nih.gov/pubmed/22228996 http://dx.doi.org/10.2147/IJN.S27285 |
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author | Armstead, Andrea L Li, Bingyun |
author_facet | Armstead, Andrea L Li, Bingyun |
author_sort | Armstead, Andrea L |
collection | PubMed |
description | Diseases such as tuberculosis, hepatitis, and HIV/AIDS are caused by intracellular pathogens and are a major burden to the global medical community. Conventional treatments for these diseases typically consist of long-term therapy with a combination of drugs, which may lead to side effects and contribute to low patient compliance. The pathogens reside within intracellular compartments of the cell, which provide additional barriers to effective treatment. Therefore, there is a need for improved and more effective therapies for such intracellular diseases. This review will summarize, for the first time, the intracellular compartments in which pathogens can reside and discuss how nanomedicine has the potential to improve intracellular disease therapy by offering properties such as targeting, sustained drug release, and drug delivery to the pathogen’s intracellular location. The characteristics of nanomedicine may prove advantageous in developing improved or alternative therapies for intracellular diseases. |
format | Online Article Text |
id | pubmed-3252676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32526762012-01-06 Nanomedicine as an emerging approach against intracellular pathogens Armstead, Andrea L Li, Bingyun Int J Nanomedicine Review Diseases such as tuberculosis, hepatitis, and HIV/AIDS are caused by intracellular pathogens and are a major burden to the global medical community. Conventional treatments for these diseases typically consist of long-term therapy with a combination of drugs, which may lead to side effects and contribute to low patient compliance. The pathogens reside within intracellular compartments of the cell, which provide additional barriers to effective treatment. Therefore, there is a need for improved and more effective therapies for such intracellular diseases. This review will summarize, for the first time, the intracellular compartments in which pathogens can reside and discuss how nanomedicine has the potential to improve intracellular disease therapy by offering properties such as targeting, sustained drug release, and drug delivery to the pathogen’s intracellular location. The characteristics of nanomedicine may prove advantageous in developing improved or alternative therapies for intracellular diseases. Dove Medical Press 2011 2011-12-09 /pmc/articles/PMC3252676/ /pubmed/22228996 http://dx.doi.org/10.2147/IJN.S27285 Text en © 2011 Armstead and Li, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Armstead, Andrea L Li, Bingyun Nanomedicine as an emerging approach against intracellular pathogens |
title | Nanomedicine as an emerging approach against intracellular pathogens |
title_full | Nanomedicine as an emerging approach against intracellular pathogens |
title_fullStr | Nanomedicine as an emerging approach against intracellular pathogens |
title_full_unstemmed | Nanomedicine as an emerging approach against intracellular pathogens |
title_short | Nanomedicine as an emerging approach against intracellular pathogens |
title_sort | nanomedicine as an emerging approach against intracellular pathogens |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252676/ https://www.ncbi.nlm.nih.gov/pubmed/22228996 http://dx.doi.org/10.2147/IJN.S27285 |
work_keys_str_mv | AT armsteadandreal nanomedicineasanemergingapproachagainstintracellularpathogens AT libingyun nanomedicineasanemergingapproachagainstintracellularpathogens |