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Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells

Six p53 wild-type cancer cell lines from infrequently p53-mutated entities (neuroblastoma, rhabdomyosarcoma, and melanoma) were continuously exposed to increasing concentrations of the murine double minute 2 inhibitor nutlin-3, resulting in the emergence of nutlin-3-resistant, p53-mutated sublines d...

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Detalles Bibliográficos
Autores principales:	Michaelis, M, Rothweiler, F, Barth, S, Cinatl, J, van Rikxoort, M, Löschmann, N, Voges, Y, Breitling, R, von Deimling, A, Rödel, F, Weber, K, Fehse, B, Mack, E, Stiewe, T, Doerr, H W, Speidel, D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252738/ https://www.ncbi.nlm.nih.gov/pubmed/22170099 http://dx.doi.org/10.1038/cddis.2011.129

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