Cargando…

Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration

Pharmacological manipulation of the type 5 metabotropic glutamate (mGlu5) receptor alters various addiction related behaviors such as drug self-administration and the extinction and reinstatement of drug-seeking behavior. However, the effects of pharmacological modulation of mGlu5 receptors on brain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cleva, Richard M., Watterson, Lucas R., Johnson, Meagan A., Olive, M. Foster
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252814/ https://www.ncbi.nlm.nih.gov/pubmed/22232603 http://dx.doi.org/10.3389/fphar.2011.00093

Ejemplares similares

Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not Relearning Following Methamphetamine Self-Administration
por: Kufahl, Peter R., et al.
Publicado: (2012)

Allosteric Modulators for mGlu Receptors
por: Gasparini, F, et al.
Publicado: (2007)

Negative Allosteric Modulators of mGlu(7) Receptor as Putative Antipsychotic Drugs
por: Cieślik, Paulina, et al.
Publicado: (2018)

In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator
por: Zuena, Anna R., et al.
Publicado: (2018)

Neurobiological Insights from mGlu Receptor Allosteric Modulation
por: O’Brien, Daniel E, et al.
Publicado: (2015)

Optical control of pain in vivo with a photoactive mGlu(5) receptor negative allosteric modulator
por: Font, Joan, et al.
Publicado: (2017)

mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling
por: Xiang, Zixiu, et al.
Publicado: (2019)

Challenges in the Discovery and Optimization of mGlu(2/4) Heterodimer Positive Allosteric Modulators
por: Fulton, Mark Gallant, et al.
Publicado: (2019)

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
por: Font, Joan, et al.
Publicado: (2018)

Positive Allosteric Modulators of Type 5 Metabotropic Glutamate Receptors (mGluR5) and Their Therapeutic Potential for the Treatment of CNS Disorders
por: Cleva, Richard M., et al.
Publicado: (2011)

Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine
por: Kufahl, Peter R, et al.
Publicado: (2013)

Differential activity of mGlu(7) allosteric modulators provides evidence for mGlu(7/8) heterodimers at hippocampal Schaffer collateral-CA1 synapses
por: Lin, Xin, et al.
Publicado: (2022)

Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813
por: Lavreysen, Hilde, et al.
Publicado: (2015)

Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain
por: Moloney, Rachel D., et al.
Publicado: (2015)

mGlu5 Receptor Functional Interactions and Addiction
por: Brown, Robyn M., et al.
Publicado: (2012)

Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction?
por: Watterson, Lucas R., et al.
Publicado: (2013)

Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
por: Wang, Xinwei, et al.
Publicado: (2023)

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
por: Turlington, Mark, et al.
Publicado: (2014)

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor
por: Lavreysen, Hilde, et al.
Publicado: (2015)

mGlu2 mechanism-based interventions to treat alcohol relapse
por: Vengeliene, Valentina, et al.
Publicado: (2022)

Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulator
por: Salt, T.E., et al.
Publicado: (2012)

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice
por: Zammataro, Magda, et al.
Publicado: (2017)

Presynaptic Release-Regulating mGlu1 Receptors in Central Nervous System
por: Pittaluga, Anna
Publicado: (2016)

The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies
por: Senter, Rebecca K., et al.
Publicado: (2016)

Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus()
por: Salt, T.E., et al.
Publicado: (2014)

Partial mGlu(5) Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG
por: Holter, Kimberly M., et al.
Publicado: (2021)

mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats
por: Ahnaou, Abdallah, et al.
Publicado: (2015)

The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu(5) receptor case study
por: Orgován, Zoltán, et al.
Publicado: (2019)

Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network
por: Tassin, Valériane, et al.
Publicado: (2016)

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists
por: Zammataro, Magda, et al.
Publicado: (2011)

Astrocytes modulate thalamic sensory processing via mGlu2 receptor activation
por: Copeland, C.S., et al.
Publicado: (2017)

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology
por: Hammond, Alexis S., et al.
Publicado: (2010)

A Light-Controlled Allosteric Modulator Unveils a Role for mGlu(4) Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex
por: Bossi, Simon, et al.
Publicado: (2018)

Capsaicin Is a Negative Allosteric Modulator of the 5-HT(3) Receptor
por: Nebrisi, Eslam El, et al.
Publicado: (2020)

Blocking glutamate mGlu(5) receptors with the negative allosteric modulator CTEP improves disease course in SOD1(G93A) mouse model of amyotrophic lateral sclerosis
por: Milanese, Marco, et al.
Publicado: (2021)

Emergence of Endocytosis-Dependent mGlu1 LTD at Nucleus Accumbens Synapses After Withdrawal From Cocaine Self-Administration
por: Scheyer, Andrew F., et al.
Publicado: (2018)

Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation
por: Langer, Kai, et al.
Publicado: (2021)

Oscillatory Deficits in the Sub-Chronic PCP Rat Model for Schizophrenia Are Reversed by mGlu5 Receptor-Positive Allosteric Modulators VU0409551 and VU0360172
por: Brown, Jessica, et al.
Publicado: (2023)

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
por: Scholler, Pauline, et al.
Publicado: (2017)

Withdrawal from Cocaine Self-administration and Yoked Cocaine Delivery Dysregulates Glutamatergic mGlu(5) and NMDA Receptors in the Rat Brain
por: Pomierny-Chamiolo, Lucyna, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_d8utqsj4me08d8c4n9khb9en6f