Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.

The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia sp. cf. C. flammea. Culture on a biomalt medium supplemented with sea salt led to the isolation of three new phthalide derivatives, i.e., marilones A–C (1–3), and the known compound silvaticol (4). The skeleton of m...

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Autores principales: Almeida, Celso, Kehraus, Stefan, Prudêncio, Miguel, König, Gabriele M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252867/
https://www.ncbi.nlm.nih.gov/pubmed/22238541
http://dx.doi.org/10.3762/bjoc.7.192
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author Almeida, Celso
Kehraus, Stefan
Prudêncio, Miguel
König, Gabriele M
author_facet Almeida, Celso
Kehraus, Stefan
Prudêncio, Miguel
König, Gabriele M
author_sort Almeida, Celso
collection PubMed
description The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia sp. cf. C. flammea. Culture on a biomalt medium supplemented with sea salt led to the isolation of three new phthalide derivatives, i.e., marilones A–C (1–3), and the known compound silvaticol (4). The skeleton of marilones A and B is most unusual, and its biosynthesis is suggested to require unique biochemical reactions considering fungal secondary metabolism. Marilone A (1) was found to have antiplasmodial activity against Plasmodium berghei liver stages with an IC(50) of 12.1 µM. Marilone B (2) showed selective antagonistic activity towards the serotonin receptor 5-HT(2B) with a K(i) value of 7.7 µM.
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spelling pubmed-32528672012-01-11 Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp. Almeida, Celso Kehraus, Stefan Prudêncio, Miguel König, Gabriele M Beilstein J Org Chem Letter The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia sp. cf. C. flammea. Culture on a biomalt medium supplemented with sea salt led to the isolation of three new phthalide derivatives, i.e., marilones A–C (1–3), and the known compound silvaticol (4). The skeleton of marilones A and B is most unusual, and its biosynthesis is suggested to require unique biochemical reactions considering fungal secondary metabolism. Marilone A (1) was found to have antiplasmodial activity against Plasmodium berghei liver stages with an IC(50) of 12.1 µM. Marilone B (2) showed selective antagonistic activity towards the serotonin receptor 5-HT(2B) with a K(i) value of 7.7 µM. Beilstein-Institut 2011-12-05 /pmc/articles/PMC3252867/ /pubmed/22238541 http://dx.doi.org/10.3762/bjoc.7.192 Text en Copyright © 2011, Almeida et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Almeida, Celso
Kehraus, Stefan
Prudêncio, Miguel
König, Gabriele M
Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.
title Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.
title_full Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.
title_fullStr Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.
title_full_unstemmed Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.
title_short Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.
title_sort marilones a–c, phthalides from the sponge-derived fungus stachylidium sp.
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252867/
https://www.ncbi.nlm.nih.gov/pubmed/22238541
http://dx.doi.org/10.3762/bjoc.7.192
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