Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes

An efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles was achieved. The synthesis involves the [3 + 2] dipolar cycloaddition of 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes. The process proceeds smoothly in moderate to excellent yields. 1,3-Diaryl-4-halo-1H-pyrazoles are found to be important i...

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Autores principales: Yang, Yiwen, Kuang, Chunxiang, Jin, Hui, Yang, Qing, Zhang, Zhongkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252870/
https://www.ncbi.nlm.nih.gov/pubmed/22238544
http://dx.doi.org/10.3762/bjoc.7.195
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author Yang, Yiwen
Kuang, Chunxiang
Jin, Hui
Yang, Qing
Zhang, Zhongkui
author_facet Yang, Yiwen
Kuang, Chunxiang
Jin, Hui
Yang, Qing
Zhang, Zhongkui
author_sort Yang, Yiwen
collection PubMed
description An efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles was achieved. The synthesis involves the [3 + 2] dipolar cycloaddition of 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes. The process proceeds smoothly in moderate to excellent yields. 1,3-Diaryl-4-halo-1H-pyrazoles are found to be important intermediates that can easily be converted into 1,2,5-triaryl-substituted pyrazoles via Pd-catalyzed C–H bond activation.
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spelling pubmed-32528702012-01-11 Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes Yang, Yiwen Kuang, Chunxiang Jin, Hui Yang, Qing Zhang, Zhongkui Beilstein J Org Chem Full Research Paper An efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles was achieved. The synthesis involves the [3 + 2] dipolar cycloaddition of 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes. The process proceeds smoothly in moderate to excellent yields. 1,3-Diaryl-4-halo-1H-pyrazoles are found to be important intermediates that can easily be converted into 1,2,5-triaryl-substituted pyrazoles via Pd-catalyzed C–H bond activation. Beilstein-Institut 2011-12-12 /pmc/articles/PMC3252870/ /pubmed/22238544 http://dx.doi.org/10.3762/bjoc.7.195 Text en Copyright © 2011, Yang et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Yang, Yiwen
Kuang, Chunxiang
Jin, Hui
Yang, Qing
Zhang, Zhongkui
Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes
title Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes
title_full Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes
title_fullStr Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes
title_full_unstemmed Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes
title_short Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes
title_sort efficient synthesis of 1,3-diaryl-4-halo-1h-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252870/
https://www.ncbi.nlm.nih.gov/pubmed/22238544
http://dx.doi.org/10.3762/bjoc.7.195
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