Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

A simple, practical and efficient continuous-flow hydration–condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access t...

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Detalles Bibliográficos
Autores principales: Rueping, Magnus, Bootwicha, Teerawut, Baars, Hannah, Sugiono, Erli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252873/
https://www.ncbi.nlm.nih.gov/pubmed/22238547
http://dx.doi.org/10.3762/bjoc.7.198
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author Rueping, Magnus
Bootwicha, Teerawut
Baars, Hannah
Sugiono, Erli
author_facet Rueping, Magnus
Bootwicha, Teerawut
Baars, Hannah
Sugiono, Erli
author_sort Rueping, Magnus
collection PubMed
description A simple, practical and efficient continuous-flow hydration–condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.
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spelling pubmed-32528732012-01-11 Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst Rueping, Magnus Bootwicha, Teerawut Baars, Hannah Sugiono, Erli Beilstein J Org Chem Full Research Paper A simple, practical and efficient continuous-flow hydration–condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale. Beilstein-Institut 2011-12-15 /pmc/articles/PMC3252873/ /pubmed/22238547 http://dx.doi.org/10.3762/bjoc.7.198 Text en Copyright © 2011, Rueping et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Rueping, Magnus
Bootwicha, Teerawut
Baars, Hannah
Sugiono, Erli
Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst
title Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst
title_full Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst
title_fullStr Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst
title_full_unstemmed Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst
title_short Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst
title_sort continuous-flow hydration–condensation reaction: synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252873/
https://www.ncbi.nlm.nih.gov/pubmed/22238547
http://dx.doi.org/10.3762/bjoc.7.198
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