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A Mutation in Intracellular Loop 4 Affects the Drug-Efflux Activity of the Yeast Multidrug Resistance ABC Transporter Pdr5p

Multidrug resistance protein Pdr5p is a yeast ATP-binding cassette (ABC) transporter in the plasma membrane. It confers multidrug resistance by active efflux of intracellular drugs. However, the highly polymorphic Pdr5p from clinical strain YJM789 loses its ability to expel azole and cyclohexmide. T...

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Detalles Bibliográficos
Autores principales:	Guo, Xiaoxian, Li, Jingkai, Wang, Tanjun, Liu, Zhenhua, Chen, Xin, Li, Yudong, Gu, Zhenglong, Mao, Xuming, Guan, Wenjun, Li, Yongquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253106/ https://www.ncbi.nlm.nih.gov/pubmed/22238618 http://dx.doi.org/10.1371/journal.pone.0029520

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