The N-Terminal DH-PH Domain of Trio Induces Cell Spreading and Migration by Regulating Lamellipodia Dynamics in a Rac1-Dependent Fashion

The guanine-nucleotide exchange factor Trio encodes two DH-PH domains that catalyze nucleotide exchange on Rac1, RhoG and RhoA. The N-terminal DH-PH domain is known to activate Rac1 and RhoG, whereas the C-terminal DH-PH domain can activate RhoA. The current study shows that the N-terminal DH-PH dom...

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Detalles Bibliográficos
Autores principales: van Rijssel, Jos, Hoogenboezem, Mark, Wester, Lynn, Hordijk, Peter L., Van Buul, Jaap D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253119/
https://www.ncbi.nlm.nih.gov/pubmed/22238672
http://dx.doi.org/10.1371/journal.pone.0029912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253119/
https://www.ncbi.nlm.nih.gov/pubmed/22238672
http://dx.doi.org/10.1371/journal.pone.0029912

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