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Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives

The mechanism of action of protein-bound polysaccharide K (PSK; KRESTIN(®)) involves the following actions: (1) recovery from immunosuppression induced by humoral factors such as transforming growth factor (TGF)-β or as a result of surgery and chemotherapy; (2) activation of antitumor immune respons...

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Autores principales: Maehara, Yoshihiko, Tsujitani, Shunichi, Saeki, Hiroshi, Oki, Eiji, Yoshinaga, Keiji, Emi, Yasunori, Morita, Masaru, Kohnoe, Shunji, Kakeji, Yoshihiro, Yano, Tokujiro, Baba, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253283/
https://www.ncbi.nlm.nih.gov/pubmed/22139128
http://dx.doi.org/10.1007/s00595-011-0075-7
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author Maehara, Yoshihiko
Tsujitani, Shunichi
Saeki, Hiroshi
Oki, Eiji
Yoshinaga, Keiji
Emi, Yasunori
Morita, Masaru
Kohnoe, Shunji
Kakeji, Yoshihiro
Yano, Tokujiro
Baba, Hideo
author_facet Maehara, Yoshihiko
Tsujitani, Shunichi
Saeki, Hiroshi
Oki, Eiji
Yoshinaga, Keiji
Emi, Yasunori
Morita, Masaru
Kohnoe, Shunji
Kakeji, Yoshihiro
Yano, Tokujiro
Baba, Hideo
author_sort Maehara, Yoshihiko
collection PubMed
description The mechanism of action of protein-bound polysaccharide K (PSK; KRESTIN(®)) involves the following actions: (1) recovery from immunosuppression induced by humoral factors such as transforming growth factor (TGF)-β or as a result of surgery and chemotherapy; (2) activation of antitumor immune responses including maturation of dendritic cells, correction of Th1/Th2 imbalance, and promotion of interleukin-15 production by monocytes; and (3) enhancement of the antitumor effect of chemotherapy by induction of apoptosis and inhibition of metastasis through direct actions on tumor cells. The clinical effectiveness of PSK has been demonstrated for various cancers. In patients with gastric or colorectal cancer, combined use of PSK with postoperative adjuvant chemotherapy prolongs survival, and this effect has been confirmed in multiple meta-analyses. For small-cell lung carcinoma, PSK in conjunction with chemotherapy prolongs the remission period. In addition, PSK has been shown to be effective against various other cancers, reduce the adverse effects of chemotherapy, and improve quality of life. Future studies should examine the effects of PSK under different host immune conditions and tumor properties, elucidate the mechanism of action exhibited in each situation, and identify biomarkers.
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spelling pubmed-32532832012-01-20 Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives Maehara, Yoshihiko Tsujitani, Shunichi Saeki, Hiroshi Oki, Eiji Yoshinaga, Keiji Emi, Yasunori Morita, Masaru Kohnoe, Shunji Kakeji, Yoshihiro Yano, Tokujiro Baba, Hideo Surg Today Review Article The mechanism of action of protein-bound polysaccharide K (PSK; KRESTIN(®)) involves the following actions: (1) recovery from immunosuppression induced by humoral factors such as transforming growth factor (TGF)-β or as a result of surgery and chemotherapy; (2) activation of antitumor immune responses including maturation of dendritic cells, correction of Th1/Th2 imbalance, and promotion of interleukin-15 production by monocytes; and (3) enhancement of the antitumor effect of chemotherapy by induction of apoptosis and inhibition of metastasis through direct actions on tumor cells. The clinical effectiveness of PSK has been demonstrated for various cancers. In patients with gastric or colorectal cancer, combined use of PSK with postoperative adjuvant chemotherapy prolongs survival, and this effect has been confirmed in multiple meta-analyses. For small-cell lung carcinoma, PSK in conjunction with chemotherapy prolongs the remission period. In addition, PSK has been shown to be effective against various other cancers, reduce the adverse effects of chemotherapy, and improve quality of life. Future studies should examine the effects of PSK under different host immune conditions and tumor properties, elucidate the mechanism of action exhibited in each situation, and identify biomarkers. Springer Japan 2011-12-06 2012 /pmc/articles/PMC3253283/ /pubmed/22139128 http://dx.doi.org/10.1007/s00595-011-0075-7 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review Article
Maehara, Yoshihiko
Tsujitani, Shunichi
Saeki, Hiroshi
Oki, Eiji
Yoshinaga, Keiji
Emi, Yasunori
Morita, Masaru
Kohnoe, Shunji
Kakeji, Yoshihiro
Yano, Tokujiro
Baba, Hideo
Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives
title Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives
title_full Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives
title_fullStr Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives
title_full_unstemmed Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives
title_short Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives
title_sort biological mechanism and clinical effect of protein-bound polysaccharide k (krestin(®)): review of development and future perspectives
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253283/
https://www.ncbi.nlm.nih.gov/pubmed/22139128
http://dx.doi.org/10.1007/s00595-011-0075-7
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