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Role of Mindin in Diabetic Nephropathy
A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a memb...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253443/ https://www.ncbi.nlm.nih.gov/pubmed/22235198 http://dx.doi.org/10.1155/2011/486305 |
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author | Murakoshi, Maki Gohda, Tomohito Tanimoto, Mitsuo Funabiki, Kazuhiko Horikoshi, Satoshi Tomino, Yasuhiko |
author_facet | Murakoshi, Maki Gohda, Tomohito Tanimoto, Mitsuo Funabiki, Kazuhiko Horikoshi, Satoshi Tomino, Yasuhiko |
author_sort | Murakoshi, Maki |
collection | PubMed |
description | A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins. Recent studies showed that mindin is essential for initiation of innate immune response and represents a unique pattern-recognition molecule in the ECM. Previously, we demonstrated that the levels of urinary mindin in patients with type 2 diabetes were higher than those in healthy individuals. We propose that urinary mindin is a potent biomarker for the development of diabetic nephropathy. |
format | Online Article Text |
id | pubmed-3253443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32534432012-01-10 Role of Mindin in Diabetic Nephropathy Murakoshi, Maki Gohda, Tomohito Tanimoto, Mitsuo Funabiki, Kazuhiko Horikoshi, Satoshi Tomino, Yasuhiko Exp Diabetes Res Review Article A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins. Recent studies showed that mindin is essential for initiation of innate immune response and represents a unique pattern-recognition molecule in the ECM. Previously, we demonstrated that the levels of urinary mindin in patients with type 2 diabetes were higher than those in healthy individuals. We propose that urinary mindin is a potent biomarker for the development of diabetic nephropathy. Hindawi Publishing Corporation 2011 2011-12-26 /pmc/articles/PMC3253443/ /pubmed/22235198 http://dx.doi.org/10.1155/2011/486305 Text en Copyright © 2011 Maki Murakoshi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Murakoshi, Maki Gohda, Tomohito Tanimoto, Mitsuo Funabiki, Kazuhiko Horikoshi, Satoshi Tomino, Yasuhiko Role of Mindin in Diabetic Nephropathy |
title | Role of Mindin in Diabetic Nephropathy |
title_full | Role of Mindin in Diabetic Nephropathy |
title_fullStr | Role of Mindin in Diabetic Nephropathy |
title_full_unstemmed | Role of Mindin in Diabetic Nephropathy |
title_short | Role of Mindin in Diabetic Nephropathy |
title_sort | role of mindin in diabetic nephropathy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253443/ https://www.ncbi.nlm.nih.gov/pubmed/22235198 http://dx.doi.org/10.1155/2011/486305 |
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