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Role of Mindin in Diabetic Nephropathy

A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a memb...

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Detalles Bibliográficos
Autores principales: Murakoshi, Maki, Gohda, Tomohito, Tanimoto, Mitsuo, Funabiki, Kazuhiko, Horikoshi, Satoshi, Tomino, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253443/
https://www.ncbi.nlm.nih.gov/pubmed/22235198
http://dx.doi.org/10.1155/2011/486305
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author Murakoshi, Maki
Gohda, Tomohito
Tanimoto, Mitsuo
Funabiki, Kazuhiko
Horikoshi, Satoshi
Tomino, Yasuhiko
author_facet Murakoshi, Maki
Gohda, Tomohito
Tanimoto, Mitsuo
Funabiki, Kazuhiko
Horikoshi, Satoshi
Tomino, Yasuhiko
author_sort Murakoshi, Maki
collection PubMed
description A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins. Recent studies showed that mindin is essential for initiation of innate immune response and represents a unique pattern-recognition molecule in the ECM. Previously, we demonstrated that the levels of urinary mindin in patients with type 2 diabetes were higher than those in healthy individuals. We propose that urinary mindin is a potent biomarker for the development of diabetic nephropathy.
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spelling pubmed-32534432012-01-10 Role of Mindin in Diabetic Nephropathy Murakoshi, Maki Gohda, Tomohito Tanimoto, Mitsuo Funabiki, Kazuhiko Horikoshi, Satoshi Tomino, Yasuhiko Exp Diabetes Res Review Article A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins. Recent studies showed that mindin is essential for initiation of innate immune response and represents a unique pattern-recognition molecule in the ECM. Previously, we demonstrated that the levels of urinary mindin in patients with type 2 diabetes were higher than those in healthy individuals. We propose that urinary mindin is a potent biomarker for the development of diabetic nephropathy. Hindawi Publishing Corporation 2011 2011-12-26 /pmc/articles/PMC3253443/ /pubmed/22235198 http://dx.doi.org/10.1155/2011/486305 Text en Copyright © 2011 Maki Murakoshi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Murakoshi, Maki
Gohda, Tomohito
Tanimoto, Mitsuo
Funabiki, Kazuhiko
Horikoshi, Satoshi
Tomino, Yasuhiko
Role of Mindin in Diabetic Nephropathy
title Role of Mindin in Diabetic Nephropathy
title_full Role of Mindin in Diabetic Nephropathy
title_fullStr Role of Mindin in Diabetic Nephropathy
title_full_unstemmed Role of Mindin in Diabetic Nephropathy
title_short Role of Mindin in Diabetic Nephropathy
title_sort role of mindin in diabetic nephropathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253443/
https://www.ncbi.nlm.nih.gov/pubmed/22235198
http://dx.doi.org/10.1155/2011/486305
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