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Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment
Systemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. Despite being grouped under JIA, it is considered to be a multifactorial autoinflammatory disease. The objective of this paper is to re...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253447/ https://www.ncbi.nlm.nih.gov/pubmed/22235382 http://dx.doi.org/10.1155/2012/271569 |
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author | Gurion, R. Lehman, T. J. A. Moorthy, L. N. |
author_facet | Gurion, R. Lehman, T. J. A. Moorthy, L. N. |
author_sort | Gurion, R. |
collection | PubMed |
description | Systemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. Despite being grouped under JIA, it is considered to be a multifactorial autoinflammatory disease. The objective of this paper is to review the epidemiology, pathogenesis, genetics, clinical manifestations, complications, therapy, prognosis, and outcome of sJIA. The presentation and clinical manifestations of sJIA have not changed much in the past several decades, but the collective understanding of the pathogenesis and the development of new targeted therapies (particularly the biologic agents) have transformed and improved the disease outcome for children with sJIA. |
format | Online Article Text |
id | pubmed-3253447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32534472012-01-10 Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment Gurion, R. Lehman, T. J. A. Moorthy, L. N. Int J Inflam Review Article Systemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. Despite being grouped under JIA, it is considered to be a multifactorial autoinflammatory disease. The objective of this paper is to review the epidemiology, pathogenesis, genetics, clinical manifestations, complications, therapy, prognosis, and outcome of sJIA. The presentation and clinical manifestations of sJIA have not changed much in the past several decades, but the collective understanding of the pathogenesis and the development of new targeted therapies (particularly the biologic agents) have transformed and improved the disease outcome for children with sJIA. Hindawi Publishing Corporation 2012 2011-12-25 /pmc/articles/PMC3253447/ /pubmed/22235382 http://dx.doi.org/10.1155/2012/271569 Text en Copyright © 2012 R. Gurion et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gurion, R. Lehman, T. J. A. Moorthy, L. N. Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment |
title | Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment |
title_full | Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment |
title_fullStr | Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment |
title_full_unstemmed | Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment |
title_short | Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment |
title_sort | systemic arthritis in children: a review of clinical presentation and treatment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253447/ https://www.ncbi.nlm.nih.gov/pubmed/22235382 http://dx.doi.org/10.1155/2012/271569 |
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