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Midkine in Inflammation
The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role of MK in acute and chronic inflammatory processes. Accordingly, several inflammatory diseases includin...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253530/ https://www.ncbi.nlm.nih.gov/pubmed/22235180 http://dx.doi.org/10.1100/2011/517152 |
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author | Weckbach, Ludwig T. Muramatsu, Takashi Walzog, Barbara |
author_facet | Weckbach, Ludwig T. Muramatsu, Takashi Walzog, Barbara |
author_sort | Weckbach, Ludwig T. |
collection | PubMed |
description | The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role of MK in acute and chronic inflammatory processes. Accordingly, several inflammatory diseases including nephritis, arthritis, atherosclerosis, colitis, and autoimmune encephalitis have been shown to be alleviated in the absence of MK in animal models. Reduced leukocyte recruitment to the sites of inflammation was found to be one important mechanism attenuating chronic inflammation when MK was absent. Furthermore, MK was found to modulate expression of proinflammatory cytokines and the expansion of regulatory T-cells. Here, we review the current understanding of the role of MK in different inflammatory disorders and summarize the knowledge of MK biology. |
format | Online Article Text |
id | pubmed-3253530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-32535302012-01-10 Midkine in Inflammation Weckbach, Ludwig T. Muramatsu, Takashi Walzog, Barbara ScientificWorldJournal Review Article The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role of MK in acute and chronic inflammatory processes. Accordingly, several inflammatory diseases including nephritis, arthritis, atherosclerosis, colitis, and autoimmune encephalitis have been shown to be alleviated in the absence of MK in animal models. Reduced leukocyte recruitment to the sites of inflammation was found to be one important mechanism attenuating chronic inflammation when MK was absent. Furthermore, MK was found to modulate expression of proinflammatory cytokines and the expansion of regulatory T-cells. Here, we review the current understanding of the role of MK in different inflammatory disorders and summarize the knowledge of MK biology. TheScientificWorldJOURNAL 2011-12-27 /pmc/articles/PMC3253530/ /pubmed/22235180 http://dx.doi.org/10.1100/2011/517152 Text en Copyright © 2011 Ludwig T. Weckbach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Weckbach, Ludwig T. Muramatsu, Takashi Walzog, Barbara Midkine in Inflammation |
title | Midkine in Inflammation |
title_full | Midkine in Inflammation |
title_fullStr | Midkine in Inflammation |
title_full_unstemmed | Midkine in Inflammation |
title_short | Midkine in Inflammation |
title_sort | midkine in inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253530/ https://www.ncbi.nlm.nih.gov/pubmed/22235180 http://dx.doi.org/10.1100/2011/517152 |
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