Chronic Administration of a Leupeptin-Derived Calpain Inhibitor Fails to Ameliorate Severe Muscle Pathology in a Canine Model of Duchenne Muscular Dystrophy

Calpains likely play a role in the pathogenesis of Duchenne muscular dystrophy (DMD). Accordingly, calpain inhibition may provide therapeutic benefit to DMD patients. In the present study, we sought to measure benefit from administration of a novel calpain inhibitor, C101, in a canine muscular dystr...

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Detalles Bibliográficos
Autores principales: Childers, Martin K., Bogan, Janet R., Bogan, Daniel J., Greiner, Hansel, Holder, Melanie, Grange, Robert W., Kornegay, Joe N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253583/
https://www.ncbi.nlm.nih.gov/pubmed/22291646
http://dx.doi.org/10.3389/fphar.2011.00089

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