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The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations *

Abstract. The presented work is a hybrid of an overview and an original research paper on peptides belonging to the adipokinetic hormone (AKH) family that are present in the corpora cardiaca of Chrysomeloidea. First, we introduce the AKH/red pigment-concentrating hormone (RPCH) peptide family. Secon...

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Autores principales: Gäde, Gerd, Marco, Heather G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pensoft Publishers 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253644/
https://www.ncbi.nlm.nih.gov/pubmed/22303105
http://dx.doi.org/10.3897/zookeys.157.1433
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author Gäde, Gerd
Marco, Heather G.
author_facet Gäde, Gerd
Marco, Heather G.
author_sort Gäde, Gerd
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description Abstract. The presented work is a hybrid of an overview and an original research paper on peptides belonging to the adipokinetic hormone (AKH) family that are present in the corpora cardiaca of Chrysomeloidea. First, we introduce the AKH/red pigment-concentrating hormone (RPCH) peptide family. Second, we collate the available primary sequence data on AKH peptides in Cerambycidae and Chrysomelidae, and we present new sequencing data (from previously unstudied species) obtained by liquid-chromatography coupled with ion trap electrospray ionisation mass spectrometry. Our expanded data set encompasses the primary structure of AKHs from seven species of Cerambycidae and three species of Chrysomelidae. All of these species synthesise the octapeptide code-named Peram-CAH-I (pGlu-Val-Asn-Phe-Ser-Pro-Asn-Trp amide). Whereas this is the sole AKH peptide in Cerambycidae, Chrysomelidae demonstrate a probable event of AKH gene duplication, thereby giving rise to an additional AKH. This second AKH peptide may be either Emppe-AKH (pGlu-Val-Asn-Phe-Thr-Pro-Asn-Trp amide) or Peram-CAH-II (pGlu-Leu-Thr-Phe-Thr-Pro-Asn-Trp amide). The peptide distribution and structural data suggest that both families are closely related and that Peram-CAH-I is the ancestral peptide. We hypothesise on the molecular evolution of Emppe-AKH and Peram-CAH-II from the ancestral peptide due to nonsynonymous missense single nucleotide polymorphism in the nucleotide coding sequence of prepro-AKH. Finally, we review the biological significance of the AKH peptides as hyperprolinaemic hormones in Chrysomeloidea, i.e. they cause an increase in the circulating concentration of proline. The mobilisation of proline has been demonstrated during flight in both cerambycid and chrysomelid beetles.
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spelling pubmed-32536442012-02-02 The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations * Gäde, Gerd Marco, Heather G. Zookeys Article Abstract. The presented work is a hybrid of an overview and an original research paper on peptides belonging to the adipokinetic hormone (AKH) family that are present in the corpora cardiaca of Chrysomeloidea. First, we introduce the AKH/red pigment-concentrating hormone (RPCH) peptide family. Second, we collate the available primary sequence data on AKH peptides in Cerambycidae and Chrysomelidae, and we present new sequencing data (from previously unstudied species) obtained by liquid-chromatography coupled with ion trap electrospray ionisation mass spectrometry. Our expanded data set encompasses the primary structure of AKHs from seven species of Cerambycidae and three species of Chrysomelidae. All of these species synthesise the octapeptide code-named Peram-CAH-I (pGlu-Val-Asn-Phe-Ser-Pro-Asn-Trp amide). Whereas this is the sole AKH peptide in Cerambycidae, Chrysomelidae demonstrate a probable event of AKH gene duplication, thereby giving rise to an additional AKH. This second AKH peptide may be either Emppe-AKH (pGlu-Val-Asn-Phe-Thr-Pro-Asn-Trp amide) or Peram-CAH-II (pGlu-Leu-Thr-Phe-Thr-Pro-Asn-Trp amide). The peptide distribution and structural data suggest that both families are closely related and that Peram-CAH-I is the ancestral peptide. We hypothesise on the molecular evolution of Emppe-AKH and Peram-CAH-II from the ancestral peptide due to nonsynonymous missense single nucleotide polymorphism in the nucleotide coding sequence of prepro-AKH. Finally, we review the biological significance of the AKH peptides as hyperprolinaemic hormones in Chrysomeloidea, i.e. they cause an increase in the circulating concentration of proline. The mobilisation of proline has been demonstrated during flight in both cerambycid and chrysomelid beetles. Pensoft Publishers 2011-12-21 /pmc/articles/PMC3253644/ /pubmed/22303105 http://dx.doi.org/10.3897/zookeys.157.1433 Text en Gerd Gäde, Heather G. Marco http://creativecommons.org/licenses/by/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Gäde, Gerd
Marco, Heather G.
The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations *
title The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations *
title_full The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations *
title_fullStr The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations *
title_full_unstemmed The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations *
title_short The adipokinetic hormone family in Chrysomeloidea: structural and functional considerations *
title_sort adipokinetic hormone family in chrysomeloidea: structural and functional considerations *
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253644/
https://www.ncbi.nlm.nih.gov/pubmed/22303105
http://dx.doi.org/10.3897/zookeys.157.1433
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