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The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive

AIM: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes. METHO...

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Autores principales: Falskov, Britt, Hermann, Thomas Steffen, Rask-Madsen, Christian, Major-Pedersen, Atheline, Christiansen, Buris, Raunsø, Jakob, Køber, Lars, Torp-Pedersen, Christian, Dominguez, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253770/
https://www.ncbi.nlm.nih.gov/pubmed/22241951
http://dx.doi.org/10.2147/VHRM.S25724
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author Falskov, Britt
Hermann, Thomas Steffen
Rask-Madsen, Christian
Major-Pedersen, Atheline
Christiansen, Buris
Raunsø, Jakob
Køber, Lars
Torp-Pedersen, Christian
Dominguez, Helena
author_facet Falskov, Britt
Hermann, Thomas Steffen
Rask-Madsen, Christian
Major-Pedersen, Atheline
Christiansen, Buris
Raunsø, Jakob
Køber, Lars
Torp-Pedersen, Christian
Dominguez, Helena
author_sort Falskov, Britt
collection PubMed
description AIM: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes. METHODS: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion. RESULTS: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% ± 6.16%, 23.50% ± 8.32%, and 22.29% ± 10.77% at the three doses respectively, compared to the healthy control group 45.96% ± 11.56%, 67.40% ± 18.11% and 84.57% ± 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% ± 7.81%, −2.35% ± 11.76%, and 5.82% ± 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08). CONCLUSION: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.
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spelling pubmed-32537702012-01-12 The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive Falskov, Britt Hermann, Thomas Steffen Rask-Madsen, Christian Major-Pedersen, Atheline Christiansen, Buris Raunsø, Jakob Køber, Lars Torp-Pedersen, Christian Dominguez, Helena Vasc Health Risk Manag Original Research AIM: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes. METHODS: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion. RESULTS: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% ± 6.16%, 23.50% ± 8.32%, and 22.29% ± 10.77% at the three doses respectively, compared to the healthy control group 45.96% ± 11.56%, 67.40% ± 18.11% and 84.57% ± 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% ± 7.81%, −2.35% ± 11.76%, and 5.82% ± 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08). CONCLUSION: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive. Dove Medical Press 2011 2011-12-19 /pmc/articles/PMC3253770/ /pubmed/22241951 http://dx.doi.org/10.2147/VHRM.S25724 Text en © 2011 Falskov et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Falskov, Britt
Hermann, Thomas Steffen
Rask-Madsen, Christian
Major-Pedersen, Atheline
Christiansen, Buris
Raunsø, Jakob
Køber, Lars
Torp-Pedersen, Christian
Dominguez, Helena
The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
title The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
title_full The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
title_fullStr The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
title_full_unstemmed The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
title_short The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
title_sort effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253770/
https://www.ncbi.nlm.nih.gov/pubmed/22241951
http://dx.doi.org/10.2147/VHRM.S25724
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