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Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes

TNFα stimulates both pro- and anti-apoptotic signalling in hepatocytes. Anti-apoptotic signalling depends on a cascade of ubiquitylation steps leading to NFκB activation. Using Sharpin-deficient mice, we show that the ubiquitin binding protein Sharpin interacts with Hoip, an E3 ligase which generate...

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Detalles Bibliográficos
Autores principales:	Sieber, Sabrina, Lange, Nicole, Kollmorgen, Gwendlyn, Erhardt, Annette, Quaas, Alexander, Gontarewicz, Arthur, Sass, Gabriele, Tiegs, Gisa, Kreienkamp, Hans-Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253811/ https://www.ncbi.nlm.nih.gov/pubmed/22253853 http://dx.doi.org/10.1371/journal.pone.0029993

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