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Serum Cystatin C Reflects the Progress of Albuminuria
BACKGROUND: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate. METHODS:...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Diabetes Association
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253971/ https://www.ncbi.nlm.nih.gov/pubmed/22247903 http://dx.doi.org/10.4093/dmj.2011.35.6.602 |
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author | Yoo, Jeong Seon Lee, Young Mi Lee, Eun Hae Kim, Ji Woon Lee, Shin Young Jeong, Ki-Cheon Kang, Shin Ae Park, Jong Suk Nam, Joo Young Ahn, Chul Woo Song, Young Duk Kim, Kyung Rae |
author_facet | Yoo, Jeong Seon Lee, Young Mi Lee, Eun Hae Kim, Ji Woon Lee, Shin Young Jeong, Ki-Cheon Kang, Shin Ae Park, Jong Suk Nam, Joo Young Ahn, Chul Woo Song, Young Duk Kim, Kyung Rae |
author_sort | Yoo, Jeong Seon |
collection | PubMed |
description | BACKGROUND: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate. METHODS: We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic. RESULTS: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR. CONCLUSION: Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients. |
format | Online Article Text |
id | pubmed-3253971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Korean Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-32539712012-01-13 Serum Cystatin C Reflects the Progress of Albuminuria Yoo, Jeong Seon Lee, Young Mi Lee, Eun Hae Kim, Ji Woon Lee, Shin Young Jeong, Ki-Cheon Kang, Shin Ae Park, Jong Suk Nam, Joo Young Ahn, Chul Woo Song, Young Duk Kim, Kyung Rae Diabetes Metab J Original Article BACKGROUND: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate. METHODS: We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic. RESULTS: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR. CONCLUSION: Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients. Korean Diabetes Association 2011-12 2011-12-26 /pmc/articles/PMC3253971/ /pubmed/22247903 http://dx.doi.org/10.4093/dmj.2011.35.6.602 Text en Copyright © 2011 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yoo, Jeong Seon Lee, Young Mi Lee, Eun Hae Kim, Ji Woon Lee, Shin Young Jeong, Ki-Cheon Kang, Shin Ae Park, Jong Suk Nam, Joo Young Ahn, Chul Woo Song, Young Duk Kim, Kyung Rae Serum Cystatin C Reflects the Progress of Albuminuria |
title | Serum Cystatin C Reflects the Progress of Albuminuria |
title_full | Serum Cystatin C Reflects the Progress of Albuminuria |
title_fullStr | Serum Cystatin C Reflects the Progress of Albuminuria |
title_full_unstemmed | Serum Cystatin C Reflects the Progress of Albuminuria |
title_short | Serum Cystatin C Reflects the Progress of Albuminuria |
title_sort | serum cystatin c reflects the progress of albuminuria |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253971/ https://www.ncbi.nlm.nih.gov/pubmed/22247903 http://dx.doi.org/10.4093/dmj.2011.35.6.602 |
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