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Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) involves considerable histological heterogeneity in terms of location and quality of the glomerular segmental lesions. The present study investigated the heterogeneity of segmental lesions in each variant of FSGS, determined by the Columbia classification, a...

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Autores principales: Taneda, Sekiko, Honda, Kazuho, Uchida, Keiko, Nitta, Kosaku, Yumura, Wako, Oda, Hideaki, Nagata, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253997/
https://www.ncbi.nlm.nih.gov/pubmed/21424374
http://dx.doi.org/10.1007/s11255-011-9932-y
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author Taneda, Sekiko
Honda, Kazuho
Uchida, Keiko
Nitta, Kosaku
Yumura, Wako
Oda, Hideaki
Nagata, Michio
author_facet Taneda, Sekiko
Honda, Kazuho
Uchida, Keiko
Nitta, Kosaku
Yumura, Wako
Oda, Hideaki
Nagata, Michio
author_sort Taneda, Sekiko
collection PubMed
description Focal segmental glomerulosclerosis (FSGS) involves considerable histological heterogeneity in terms of location and quality of the glomerular segmental lesions. The present study investigated the heterogeneity of segmental lesions in each variant of FSGS, determined by the Columbia classification, and its clinical relevance. All glomerular segmental lesions of 80 cases of primary FSGS were evaluated histologically based on location [tip (TIP), perihilar (PH), or not otherwise specified (NOS)], and quality (cellular or fibrous). Among the 1,299 glomeruli of the 80 biopsy specimens, 210 glomeruli (16.2%) had segmental lesions, comprising 57 (27%) cellular TIP, 4 (2%) fibrous TIP, 42 (20%) cellular NOS, 86 (41%) fibrous NOS, and 21 (10%) fibrous PH lesions. Each case was also classified into one of the five histological variants of the Columbia classification: collapsing (COL), TIP, cellular (CEL), PH, or NOS. Overlap of segmental lesions in different location categories was seen in the COL, TIP, and PH variants, and heterogeneity of quality was apparent in the COL and CEL variants. Histological findings of the CEL variant (endocapillary hypercellularity) were observed in nine of the 13 COL variants. Both location and quality correlated with disease duration, degree of proteinuria, and histological severity of global glomerular sclerosis and tubulo-interstitial lesions. These results demonstrated the histological heterogeneity of glomerular segmental lesions in all variants of the Columbia classification, except NOS. However, the fidelity of location and dominance of histological features were generally conserved in the TIP and PH variants. The COL and CEL variants warrant further investigation because of their overlapping histological findings and apparent histological heterogeneity in the glomerular segmental lesions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11255-011-9932-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-32539972012-01-20 Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis Taneda, Sekiko Honda, Kazuho Uchida, Keiko Nitta, Kosaku Yumura, Wako Oda, Hideaki Nagata, Michio Int Urol Nephrol Nephrology – Original Paper Focal segmental glomerulosclerosis (FSGS) involves considerable histological heterogeneity in terms of location and quality of the glomerular segmental lesions. The present study investigated the heterogeneity of segmental lesions in each variant of FSGS, determined by the Columbia classification, and its clinical relevance. All glomerular segmental lesions of 80 cases of primary FSGS were evaluated histologically based on location [tip (TIP), perihilar (PH), or not otherwise specified (NOS)], and quality (cellular or fibrous). Among the 1,299 glomeruli of the 80 biopsy specimens, 210 glomeruli (16.2%) had segmental lesions, comprising 57 (27%) cellular TIP, 4 (2%) fibrous TIP, 42 (20%) cellular NOS, 86 (41%) fibrous NOS, and 21 (10%) fibrous PH lesions. Each case was also classified into one of the five histological variants of the Columbia classification: collapsing (COL), TIP, cellular (CEL), PH, or NOS. Overlap of segmental lesions in different location categories was seen in the COL, TIP, and PH variants, and heterogeneity of quality was apparent in the COL and CEL variants. Histological findings of the CEL variant (endocapillary hypercellularity) were observed in nine of the 13 COL variants. Both location and quality correlated with disease duration, degree of proteinuria, and histological severity of global glomerular sclerosis and tubulo-interstitial lesions. These results demonstrated the histological heterogeneity of glomerular segmental lesions in all variants of the Columbia classification, except NOS. However, the fidelity of location and dominance of histological features were generally conserved in the TIP and PH variants. The COL and CEL variants warrant further investigation because of their overlapping histological findings and apparent histological heterogeneity in the glomerular segmental lesions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11255-011-9932-y) contains supplementary material, which is available to authorized users. Springer Netherlands 2011-03-19 2012 /pmc/articles/PMC3253997/ /pubmed/21424374 http://dx.doi.org/10.1007/s11255-011-9932-y Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Nephrology – Original Paper
Taneda, Sekiko
Honda, Kazuho
Uchida, Keiko
Nitta, Kosaku
Yumura, Wako
Oda, Hideaki
Nagata, Michio
Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis
title Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis
title_full Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis
title_fullStr Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis
title_full_unstemmed Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis
title_short Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis
title_sort histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis
topic Nephrology – Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253997/
https://www.ncbi.nlm.nih.gov/pubmed/21424374
http://dx.doi.org/10.1007/s11255-011-9932-y
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