Regulatory Immunotherapy in Bone Marrow Transplantation

Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populati...

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Autores principales: Morales-Tirado, Vanessa, Luszczek, Wioleta, van der Merwe, Marié, Pillai, Asha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254014/
https://www.ncbi.nlm.nih.gov/pubmed/22262950
http://dx.doi.org/10.1100/2011/768948
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author Morales-Tirado, Vanessa
Luszczek, Wioleta
van der Merwe, Marié
Pillai, Asha
author_facet Morales-Tirado, Vanessa
Luszczek, Wioleta
van der Merwe, Marié
Pillai, Asha
author_sort Morales-Tirado, Vanessa
collection PubMed
description Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.
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spelling pubmed-32540142012-01-19 Regulatory Immunotherapy in Bone Marrow Transplantation Morales-Tirado, Vanessa Luszczek, Wioleta van der Merwe, Marié Pillai, Asha ScientificWorldJournal Review Article Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT. TheScientificWorldJOURNAL 2012-01-02 /pmc/articles/PMC3254014/ /pubmed/22262950 http://dx.doi.org/10.1100/2011/768948 Text en Copyright © 2011 Vanessa Morales-Tirado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Morales-Tirado, Vanessa
Luszczek, Wioleta
van der Merwe, Marié
Pillai, Asha
Regulatory Immunotherapy in Bone Marrow Transplantation
title Regulatory Immunotherapy in Bone Marrow Transplantation
title_full Regulatory Immunotherapy in Bone Marrow Transplantation
title_fullStr Regulatory Immunotherapy in Bone Marrow Transplantation
title_full_unstemmed Regulatory Immunotherapy in Bone Marrow Transplantation
title_short Regulatory Immunotherapy in Bone Marrow Transplantation
title_sort regulatory immunotherapy in bone marrow transplantation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254014/
https://www.ncbi.nlm.nih.gov/pubmed/22262950
http://dx.doi.org/10.1100/2011/768948
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