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Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles
BACKGROUND: Many serious diseases have a genetic basis which, from an evolutionary point of view, should have been selected against, resulting in very low frequencies. The remarkable sustained prevalence of a number of disease-associated alleles is therefore surprising. We believe that antagonistic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254080/ https://www.ncbi.nlm.nih.gov/pubmed/22151998 http://dx.doi.org/10.1186/1471-2350-12-160 |