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Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances
Celiac disease (CD) is an immune-mediated enteropathy triggered by exposure to wheat gluten and similar proteins found in rye and barley that affects genetically susceptible persons. This immune-mediated enteropathy is characterized by villous atrophy, intraepithelial lymphocytosis, and crypt hyperp...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254208/ https://www.ncbi.nlm.nih.gov/pubmed/22235174 http://dx.doi.org/10.2147/CEG.S8315 |
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author | Scanlon, Samantha A Murray, Joseph A |
author_facet | Scanlon, Samantha A Murray, Joseph A |
author_sort | Scanlon, Samantha A |
collection | PubMed |
description | Celiac disease (CD) is an immune-mediated enteropathy triggered by exposure to wheat gluten and similar proteins found in rye and barley that affects genetically susceptible persons. This immune-mediated enteropathy is characterized by villous atrophy, intraepithelial lymphocytosis, and crypt hyperplasia. Once thought a disease that largely presented with malnourished children, the wide spectrum of disease activity is now better recognized and this has resulted in a shift in the presenting symptoms of most patients with CD. New advances in testing, both serologic and endoscopic, have dramatically increased the detection and diagnosis of CD. While the gluten-free diet is still the only treatment for CD, recent investigations have explored alternative approaches, including the use of altered nonimmunogenic wheat variants, enzymatic degradation of gluten, tissue transglutaminase inhibitors, induction of tolerance, and peptides to restore integrity to intestinal tight junctions. |
format | Online Article Text |
id | pubmed-3254208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32542082012-01-10 Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances Scanlon, Samantha A Murray, Joseph A Clin Exp Gastroenterol Review Celiac disease (CD) is an immune-mediated enteropathy triggered by exposure to wheat gluten and similar proteins found in rye and barley that affects genetically susceptible persons. This immune-mediated enteropathy is characterized by villous atrophy, intraepithelial lymphocytosis, and crypt hyperplasia. Once thought a disease that largely presented with malnourished children, the wide spectrum of disease activity is now better recognized and this has resulted in a shift in the presenting symptoms of most patients with CD. New advances in testing, both serologic and endoscopic, have dramatically increased the detection and diagnosis of CD. While the gluten-free diet is still the only treatment for CD, recent investigations have explored alternative approaches, including the use of altered nonimmunogenic wheat variants, enzymatic degradation of gluten, tissue transglutaminase inhibitors, induction of tolerance, and peptides to restore integrity to intestinal tight junctions. Dove Medical Press 2011-12-19 /pmc/articles/PMC3254208/ /pubmed/22235174 http://dx.doi.org/10.2147/CEG.S8315 Text en © 2011 Scanlon and Murray, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Scanlon, Samantha A Murray, Joseph A Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances |
title | Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances |
title_full | Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances |
title_fullStr | Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances |
title_full_unstemmed | Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances |
title_short | Update on celiac disease – etiology, differential diagnosis, drug targets, and management advances |
title_sort | update on celiac disease – etiology, differential diagnosis, drug targets, and management advances |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254208/ https://www.ncbi.nlm.nih.gov/pubmed/22235174 http://dx.doi.org/10.2147/CEG.S8315 |
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