Cyclo­linopeptide B methanol tris­olvate

The title compound, C(56)H(83)N(9)O(9)S·3CH(3)OH, is a methanol tris­olvate of the cyclo­linopeptide cyclo(Met(1)—Leu(2)—Ile(3)—Pro(4)—Pro(5)—Phe(6)—Phe(7)—Val(8)—Ile(9)) (henceforth referred to as CLP-B), which was isolated from flaxseed oil. All the amino acid residues are in an l-configuration based on the CORN rule. The cyclic nona­peptide exhibits eight trans peptide bonds and one cis peptide bond observed between the two proline residues. The conformation is stabilized by an α-turn and two consecutive β-turns each containing a N—H⋯O hydrogen bond between the carbonyl group O atom of the first residue and the amide group H atom of the fourth (α-turn) or the third residue (β-turns), repectively. In the crystal, the components of the structure are linked by N—H⋯O and O—H⋯O hydrogen bonds into chains parallel to the a axis.