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(2R)-8-Benzyl-2-[(S)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one
The crystal of the title compound, C(21)H(23)NO(2), was chosen from a conglomerate formed by a racemic mixture. An intramolecular hydrogen bond is formed between hydroxy group and heterocyclic N atom of the azabicyclo[3.2.1]octan-3-one system. The crystal structure is stabilized by C—H⋯O intera...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254493/ https://www.ncbi.nlm.nih.gov/pubmed/22259435 http://dx.doi.org/10.1107/S1600536811053190 |
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author | Brzezinski, Krzysztof Lazny, Ryszard Sienkiewicz, Michal Wojtulewski, Sławomir Dauter, Zbigniew |
author_facet | Brzezinski, Krzysztof Lazny, Ryszard Sienkiewicz, Michal Wojtulewski, Sławomir Dauter, Zbigniew |
author_sort | Brzezinski, Krzysztof |
collection | PubMed |
description | The crystal of the title compound, C(21)H(23)NO(2), was chosen from a conglomerate formed by a racemic mixture. An intramolecular hydrogen bond is formed between hydroxy group and heterocyclic N atom of the azabicyclo[3.2.1]octan-3-one system. The crystal structure is stabilized by C—H⋯O interactions between aliphatic C—H groups and the carbonyl O atom. For the title chiral crystal, the highly redundant and accurate diffraction data set collected with low energy copper radiation gave a Flack parameter of 0.12 (18) for anomalous scattering effects originating from O atoms. |
format | Online Article Text |
id | pubmed-3254493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-32544932012-01-18 (2R)-8-Benzyl-2-[(S)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one Brzezinski, Krzysztof Lazny, Ryszard Sienkiewicz, Michal Wojtulewski, Sławomir Dauter, Zbigniew Acta Crystallogr Sect E Struct Rep Online Organic Papers The crystal of the title compound, C(21)H(23)NO(2), was chosen from a conglomerate formed by a racemic mixture. An intramolecular hydrogen bond is formed between hydroxy group and heterocyclic N atom of the azabicyclo[3.2.1]octan-3-one system. The crystal structure is stabilized by C—H⋯O interactions between aliphatic C—H groups and the carbonyl O atom. For the title chiral crystal, the highly redundant and accurate diffraction data set collected with low energy copper radiation gave a Flack parameter of 0.12 (18) for anomalous scattering effects originating from O atoms. International Union of Crystallography 2011-12-17 /pmc/articles/PMC3254493/ /pubmed/22259435 http://dx.doi.org/10.1107/S1600536811053190 Text en © Brzezinski et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Brzezinski, Krzysztof Lazny, Ryszard Sienkiewicz, Michal Wojtulewski, Sławomir Dauter, Zbigniew (2R)-8-Benzyl-2-[(S)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one |
title | (2R)-8-Benzyl-2-[(S)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one |
title_full | (2R)-8-Benzyl-2-[(S)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one |
title_fullStr | (2R)-8-Benzyl-2-[(S)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one |
title_full_unstemmed | (2R)-8-Benzyl-2-[(S)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one |
title_short | (2R)-8-Benzyl-2-[(S)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one |
title_sort | (2r)-8-benzyl-2-[(s)-hydroxy(phenyl)methyl]-8-azabicyclo[3.2.1]octan-3-one |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254493/ https://www.ncbi.nlm.nih.gov/pubmed/22259435 http://dx.doi.org/10.1107/S1600536811053190 |
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