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(2R)-8-Benzyl-2-[(S)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one

The crystal of the title compound, C(21)H(23)NO(2), was chosen from a conglomerate formed by a racemic mixture. An intra­molecular hydrogen bond is formed between hy­droxy group and heterocyclic N atom of the aza­bicyclo­[3.2.1]octan-3-one system. The crystal structure is stabilized by C—H⋯O inter­a...

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Autores principales: Brzezinski, Krzysztof, Lazny, Ryszard, Sienkiewicz, Michal, Wojtulewski, Sławomir, Dauter, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254493/
https://www.ncbi.nlm.nih.gov/pubmed/22259435
http://dx.doi.org/10.1107/S1600536811053190
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author Brzezinski, Krzysztof
Lazny, Ryszard
Sienkiewicz, Michal
Wojtulewski, Sławomir
Dauter, Zbigniew
author_facet Brzezinski, Krzysztof
Lazny, Ryszard
Sienkiewicz, Michal
Wojtulewski, Sławomir
Dauter, Zbigniew
author_sort Brzezinski, Krzysztof
collection PubMed
description The crystal of the title compound, C(21)H(23)NO(2), was chosen from a conglomerate formed by a racemic mixture. An intra­molecular hydrogen bond is formed between hy­droxy group and heterocyclic N atom of the aza­bicyclo­[3.2.1]octan-3-one system. The crystal structure is stabilized by C—H⋯O inter­actions between aliphatic C—H groups and the carbonyl O atom. For the title chiral crystal, the highly redundant and accurate diffraction data set collected with low energy copper radiation gave a Flack parameter of 0.12 (18) for anomalous scattering effects originating from O atoms.
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spelling pubmed-32544932012-01-18 (2R)-8-Benzyl-2-[(S)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one Brzezinski, Krzysztof Lazny, Ryszard Sienkiewicz, Michal Wojtulewski, Sławomir Dauter, Zbigniew Acta Crystallogr Sect E Struct Rep Online Organic Papers The crystal of the title compound, C(21)H(23)NO(2), was chosen from a conglomerate formed by a racemic mixture. An intra­molecular hydrogen bond is formed between hy­droxy group and heterocyclic N atom of the aza­bicyclo­[3.2.1]octan-3-one system. The crystal structure is stabilized by C—H⋯O inter­actions between aliphatic C—H groups and the carbonyl O atom. For the title chiral crystal, the highly redundant and accurate diffraction data set collected with low energy copper radiation gave a Flack parameter of 0.12 (18) for anomalous scattering effects originating from O atoms. International Union of Crystallography 2011-12-17 /pmc/articles/PMC3254493/ /pubmed/22259435 http://dx.doi.org/10.1107/S1600536811053190 Text en © Brzezinski et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Brzezinski, Krzysztof
Lazny, Ryszard
Sienkiewicz, Michal
Wojtulewski, Sławomir
Dauter, Zbigniew
(2R)-8-Benzyl-2-[(S)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one
title (2R)-8-Benzyl-2-[(S)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one
title_full (2R)-8-Benzyl-2-[(S)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one
title_fullStr (2R)-8-Benzyl-2-[(S)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one
title_full_unstemmed (2R)-8-Benzyl-2-[(S)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one
title_short (2R)-8-Benzyl-2-[(S)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one
title_sort (2r)-8-benzyl-2-[(s)-hy­droxy(phen­yl)meth­yl]-8-aza­bicyclo­[3.2.1]octan-3-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254493/
https://www.ncbi.nlm.nih.gov/pubmed/22259435
http://dx.doi.org/10.1107/S1600536811053190
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