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Increase in concentration of soluble HLA-G in high-quality embryos after intracytoplasmic sperm injection

Non-invasive methods are normally preferred to conventional invasive methods when selecting suitable embryos to improve pregnancy rates after assisted reproduction techniques. One of the most recognized non-invasive methods is to examine the supernatants of embryo culture media. Soluble human leukoc...

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Detalles Bibliográficos
Autores principales: Heidari, Mohammad Hassan, Novin, Marefat Ghaffari, Ahmadi, Farzaneh, Khorshid, Mehran, Najafi, Tohid, Molouki, Aidin, Salehpour, Saghar, Bandehpour, Mojgan, Heidari, Matineh, Sato, Eimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Anatomists 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254887/
https://www.ncbi.nlm.nih.gov/pubmed/22254162
http://dx.doi.org/10.5115/acb.2011.44.4.331
Descripción
Sumario:Non-invasive methods are normally preferred to conventional invasive methods when selecting suitable embryos to improve pregnancy rates after assisted reproduction techniques. One of the most recognized non-invasive methods is to examine the supernatants of embryo culture media. Soluble human leukocyte antigen, class I, G (sHLA-G) antigen is a non-classical class I molecule that has been widely considered as a marker of pregnancy failure or implantation success. In the current study of some Iranian patients, we examined the concentration of sHLA-G at different time points after intracytoplasmic sperm injection and compared the rates to the morphology and quality of the selected embryos. We showed that the concentration of sHLA-G increases over time in high-quality embryos. We conclude that there is a positive relationship between morphology, quality, and sHLA-G concentration. We suggest that this relationship can be used to increase the chance of a successful pregnancy.