Cargando…

Optical imaging of metabolism in HER2 overexpressing breast cancer cells

The optical redox ratio (fluorescence intensity of NADH divided by that of FAD), was acquired for a panel of breast cancer cell lines to investigate how overexpression of human epidermal growth factor receptor 2 (HER2) affects tumor cell metabolism, and how tumor metabolism may be altered in respons...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walsh, Alex, Cook, Rebecca S., Rexer, Brent, Arteaga, Carlos L., Skala, Melissa C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Optical Society of America 2011
Materias:	Cell Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255344/ https://www.ncbi.nlm.nih.gov/pubmed/22254170 http://dx.doi.org/10.1364/BOE.3.000075

Ejemplares similares

Direct inhibition of PI3K in combination with dual HER2 inhibitors is required for optimal antitumor activity in HER2+ breast cancer cells
por: Rexer, Brent N, et al.
Publicado: (2014)

H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation via heregulin production and activation of HER3
por: Chakrabarty, Anindita, et al.
Publicado: (2010)

Drug response in organoids generated from frozen primary tumor tissues
por: Walsh, Alex J., et al.
Publicado: (2016)

Author Correction: Drug response in organoids generated from frozen primary tumor tissues
por: Walsh, Alex J., et al.
Publicado: (2019)

Trastuzumab, an appropriate first-line single-agent therapy for HER2-overexpressing metastatic breast cancer
por: Arteaga, Carlos L
Publicado: (2003)

Outsmarting cancer: the power of hybrid genomic/proteomic biomarkers to predict drug response
por: Rexer, Brent N, et al.
Publicado: (2014)

In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish
por: Miskolci, Veronika, et al.
Publicado: (2022)

Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer
por: Miller, Todd W, et al.
Publicado: (2011)

Optical Metabolic Imaging of Treatment Response in Human Head and Neck Squamous Cell Carcinoma
por: Shah, Amy T., et al.
Publicado: (2014)

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response
por: Walsh, Alex J., et al.
Publicado: (2016)

Impact of anti-HER2 therapy on overall survival in HER2-overexpressing breast cancer patients with brain metastases
por: Bartsch, R, et al.
Publicado: (2012)

A prospective study to assess the clinical utility of serum HER2 extracellular domain in breast cancer with HER2 overexpression
por: Reix, Nathalie, et al.
Publicado: (2016)

Mouse models and anti-HER2 therapies
por: Hanker, Ariella B., et al.
Publicado: (2013)

Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers
por: Young, Christian D., et al.
Publicado: (2015)

Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients
por: Zhao, Xiangshan, et al.
Publicado: (2012)

Extracellular pH affects the fluorescence lifetimes of metabolic co-factors
por: Schmitz, Rebecca, et al.
Publicado: (2021)

Trastuzumab and Gemcitabine in Pretreated HER2 Overexpressing Metastatic Breast Cancer Patients: Retrospective Analysis of Our Series
por: Di Lauro, Vincenzo, et al.
Publicado: (2012)

Phase I study of lapatinib plus vinorelbine in patients with locally advanced or metastatic breast cancer overexpressing HER2
por: Brain, E, et al.
Publicado: (2012)

HER2-overexpressing breast cancer: FDG uptake after two cycles of chemotherapy predicts the outcome of neoadjuvant treatment
por: Groheux, D, et al.
Publicado: (2013)

Simultaneous optical measurements of cell motility and growth
por: Sridharan, Shamira, et al.
Publicado: (2011)

HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer
por: Lipton, Allan, et al.
Publicado: (2013)

Optical fiber light source directs neurite growth
por: Jesse, Forrest, et al.
Publicado: (2013)

T-bet expression in intratumoral lymphoid structures after neoadjuvant trastuzumab plus docetaxel for HER2-overexpressing breast carcinoma predicts survival
por: Ladoire, S, et al.
Publicado: (2011)

Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
por: Rexer, Brent N., et al.
Publicado: (2011)

Phase II study of lapatinib in combination with vinorelbine, as first or second-line therapy in women with HER2 overexpressing metastatic breast cancer
por: Chew, Helen Kent, et al.
Publicado: (2014)

Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids()
por: Sharick, Joe T., et al.
Publicado: (2019)

Low Level of Her-2 Locus Amplification by Fluorescent In Situ Hybridization Does Not Correlate with Her-2 Protein Overexpression by Immunohistochemistry in Barrett's Esophagus
por: Rygiel, Agnieszka M., et al.
Publicado: (2010)

The role of neoadjuvant her2-targeted therapies in her2-overexpressing breast cancers
por: Lemieux, J., et al.
Publicado: (2009)

Predictors of pathologic complete response to neoadjuvant treatment in HER2-overexpressing breast cancer: a retrospective analysis using real-world data
por: Saffie Vega, Isabel, et al.
Publicado: (2022)

Integrated optical transfection system using a microlens fiber combined with microfluidic gene delivery
por: Ma, N., et al.
Publicado: (2010)

Impact of Her-2 Overexpression on Survival of Patients with Metastatic Breast Cancer
por: dos Santos, Giovana Tavares, et al.
Publicado: (2017)

Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors
por: Yeh, Elizabeth S., et al.
Publicado: (2014)

Trastuzumab treatment improves brain metastasis outcomes through control and durable prolongation of systemic extracranial disease in HER2-overexpressing breast cancer patients
por: Park, Y H, et al.
Publicado: (2009)

A83-01 inhibits TGF-β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells
por: Wu, Yanyuan, et al.
Publicado: (2017)

Classifying T cell activity in autofluorescence intensity images with convolutional neural networks
por: Wang, Zijie J., et al.
Publicado: (2019)

Metabolic Imaging of Head and Neck Cancer Organoids
por: Shah, Amy T., et al.
Publicado: (2017)

The role of her2-targeted therapies in women with her2-overexpressing metastatic breast cancer
por: Dent, S., et al.
Publicado: (2009)

ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer
por: Pinhel, Isabel, et al.
Publicado: (2012)

Comparison of tumors with HER2 overexpression versus HER2 amplification in HER2-positive breast cancer patients
por: Horimoto, Yoshiya, et al.
Publicado: (2022)

HER2/HER3 heterodimers and p21 expression are capable of predicting adjuvant trastuzumab response in HER2+ breast cancer
por: Green, Andrew R., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_2jgt1e8a8jres9cvq99t7pgp42