LEAVES EXTRACT OF MURRAYA KOENIGII LINN FOR ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY IN ANIMAL MODELS

This work has been done for the investigation of the anti-inflammatory and analgesic activity of methanol extract of dried leaves of Murraya koenigii Linn by oral administration at dose of 100, 200 and 400 mg/kg body weight, to healthy animals. Extract was studied for its anti-inflammatory activity by using carrageenan-induced hind paw edema in albino rats and the mean increase in paw volume and % inhibition in paw volume were measured plethysmometrically at different time intervals after carrageenan (1% w/v) injection. Extract was also evaluated for analgesic activity using Eddy's hot plate method and formalin induced paw licking method in albino rats. The methanol extract showed significant (P < 0.001) reduction in the carrageenan-induced paw edema and analgesic activity evidenced by increase in the reaction time by eddy's hot plate method and percentage increase in pain in formalin test. The methanol extract showed anti-inflammatory and analgesic effect in dose dependent manner when compared with the control and standard drug, diclofenac sodium (10mg/kg, p.o). These inhibitions were statistically significant (P < 0.05). Thus our investigation suggests a potential benefit of Murraya koenigii in treating conditions associated with inflammatory pain.