Detachment and recovery index: A new parameter measuring powder compressibility

This investigation introduces a simple and reliable approach to measure the compressibility of some direct compression excipients in tablet systems made from compressible components. The claim made here is that: the total reduction, ΔL(T), in the thickness of a tablet batch due to compression at a confined machine settings is the integral sum of small reductions generated by the compressible components in the batch. The reduction value, ΔL(E), generated by a single or a blend of excipients in a batch could be calculated and was found to correlate to its concentration, C, by the relation: ΔL(E) = A(E).C(x). The constants AE and x concern the reduction tendency, RT, of the excipient particles due to compression, and detachment and recovery index (DRI), respectively. Some physicomechanical parameters characterizing the compression behavior of an excipient in a tablet batch could be determined and were found to be functions of the determine DRI of the excipient in the batch.