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Ocular inserts — Advancement in therapy of eye diseases
The ocular insert represents a significant advancement in the therapy of eye disease. Ocular inserts are defined as sterile, thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into the cul-de-sac or conjuctival sac, whose size and shape are especially designed for op...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255407/ https://www.ncbi.nlm.nih.gov/pubmed/22247860 http://dx.doi.org/10.4103/0110-5558.72419 |
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author | Kumari, Anita Sharma, Pramod K. Garg, Vipin K. Garg, Garima |
author_facet | Kumari, Anita Sharma, Pramod K. Garg, Vipin K. Garg, Garima |
author_sort | Kumari, Anita |
collection | PubMed |
description | The ocular insert represents a significant advancement in the therapy of eye disease. Ocular inserts are defined as sterile, thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into the cul-de-sac or conjuctival sac, whose size and shape are especially designed for ophthalmic application. They are composed of a polymeric support that may or may not contain a drug. The drug can later be incorporated as dispersion or a solution in the polymeric support. They offer several advantages as increased ocular residence and sustained release of medication into the eye. The insert includes a body portion sized to position within a lachrymal canaliculus of the eyelid. The inserts are classified according to their solubility as insoluble, soluble, or bioerodible inserts. The release of drug from the insert depends upon the diffusion, osmosis, and bioerosion of the drug, and this article is an attempt to present a brief about this newer drug delivery system. |
format | Online Article Text |
id | pubmed-3255407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32554072012-01-13 Ocular inserts — Advancement in therapy of eye diseases Kumari, Anita Sharma, Pramod K. Garg, Vipin K. Garg, Garima J Adv Pharm Technol Res Review Article The ocular insert represents a significant advancement in the therapy of eye disease. Ocular inserts are defined as sterile, thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into the cul-de-sac or conjuctival sac, whose size and shape are especially designed for ophthalmic application. They are composed of a polymeric support that may or may not contain a drug. The drug can later be incorporated as dispersion or a solution in the polymeric support. They offer several advantages as increased ocular residence and sustained release of medication into the eye. The insert includes a body portion sized to position within a lachrymal canaliculus of the eyelid. The inserts are classified according to their solubility as insoluble, soluble, or bioerodible inserts. The release of drug from the insert depends upon the diffusion, osmosis, and bioerosion of the drug, and this article is an attempt to present a brief about this newer drug delivery system. Medknow Publications & Media Pvt Ltd 2010 /pmc/articles/PMC3255407/ /pubmed/22247860 http://dx.doi.org/10.4103/0110-5558.72419 Text en Copyright: © Journal of Advanced Pharmaceutical Technology & Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kumari, Anita Sharma, Pramod K. Garg, Vipin K. Garg, Garima Ocular inserts — Advancement in therapy of eye diseases |
title | Ocular inserts — Advancement in therapy of eye diseases |
title_full | Ocular inserts — Advancement in therapy of eye diseases |
title_fullStr | Ocular inserts — Advancement in therapy of eye diseases |
title_full_unstemmed | Ocular inserts — Advancement in therapy of eye diseases |
title_short | Ocular inserts — Advancement in therapy of eye diseases |
title_sort | ocular inserts — advancement in therapy of eye diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255407/ https://www.ncbi.nlm.nih.gov/pubmed/22247860 http://dx.doi.org/10.4103/0110-5558.72419 |
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