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Assessment of the antidiabetic potential of Cassia grandis using an in vivo model

The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal...

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Autores principales: Lodha, Sandesh R., Joshi, Shrikant V., Vyas, Bhavin A., Upadhye, Mohini C., Kirve, Megha S., Salunke, Shweta S., Kadu, Sheetal K., Rogye, Manasi V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255413/
https://www.ncbi.nlm.nih.gov/pubmed/22247866
http://dx.doi.org/10.4103/0110-5558.72429
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author Lodha, Sandesh R.
Joshi, Shrikant V.
Vyas, Bhavin A.
Upadhye, Mohini C.
Kirve, Megha S.
Salunke, Shweta S.
Kadu, Sheetal K.
Rogye, Manasi V.
author_facet Lodha, Sandesh R.
Joshi, Shrikant V.
Vyas, Bhavin A.
Upadhye, Mohini C.
Kirve, Megha S.
Salunke, Shweta S.
Kadu, Sheetal K.
Rogye, Manasi V.
author_sort Lodha, Sandesh R.
collection PubMed
description The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal in the glucose tolerance test. In alloxan-induced diabetic rats the maximum reduction in blood glucose was observed after three hours, at a dose level of 150 mg/kg of body weight. The percentage of protection given by the aqueous and ethanolic extracts was 32.72 and 46.42%, respectively. In the long-term treatment of alloxan-induced diabetic rats, the degree of protection was determined by measuring the blood glucose, cholesterol, and triglycerides on the tenth day. Both the extracts showed a significant antidiabetic activity comparable to that of glibenclamide. These results showed that the Cassia grandis possessed significant antidiabetic activity.
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spelling pubmed-32554132012-01-13 Assessment of the antidiabetic potential of Cassia grandis using an in vivo model Lodha, Sandesh R. Joshi, Shrikant V. Vyas, Bhavin A. Upadhye, Mohini C. Kirve, Megha S. Salunke, Shweta S. Kadu, Sheetal K. Rogye, Manasi V. J Adv Pharm Technol Res Original Article The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal in the glucose tolerance test. In alloxan-induced diabetic rats the maximum reduction in blood glucose was observed after three hours, at a dose level of 150 mg/kg of body weight. The percentage of protection given by the aqueous and ethanolic extracts was 32.72 and 46.42%, respectively. In the long-term treatment of alloxan-induced diabetic rats, the degree of protection was determined by measuring the blood glucose, cholesterol, and triglycerides on the tenth day. Both the extracts showed a significant antidiabetic activity comparable to that of glibenclamide. These results showed that the Cassia grandis possessed significant antidiabetic activity. Medknow Publications & Media Pvt Ltd 2010 /pmc/articles/PMC3255413/ /pubmed/22247866 http://dx.doi.org/10.4103/0110-5558.72429 Text en Copyright: © Journal of Advanced Pharmaceutical Technology & Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lodha, Sandesh R.
Joshi, Shrikant V.
Vyas, Bhavin A.
Upadhye, Mohini C.
Kirve, Megha S.
Salunke, Shweta S.
Kadu, Sheetal K.
Rogye, Manasi V.
Assessment of the antidiabetic potential of Cassia grandis using an in vivo model
title Assessment of the antidiabetic potential of Cassia grandis using an in vivo model
title_full Assessment of the antidiabetic potential of Cassia grandis using an in vivo model
title_fullStr Assessment of the antidiabetic potential of Cassia grandis using an in vivo model
title_full_unstemmed Assessment of the antidiabetic potential of Cassia grandis using an in vivo model
title_short Assessment of the antidiabetic potential of Cassia grandis using an in vivo model
title_sort assessment of the antidiabetic potential of cassia grandis using an in vivo model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255413/
https://www.ncbi.nlm.nih.gov/pubmed/22247866
http://dx.doi.org/10.4103/0110-5558.72429
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