Cargando…

Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a maladaptive response by affecting several metabolic and s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Naudi, Alba, Jove, Mariona, Ayala, Victoria, Cassanye, Anna, Serrano, Jose, Gonzalo, Hugo, Boada, Jordi, Prat, Joan, Portero-Otin, Manuel, Pamplona, Reinald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255456/ https://www.ncbi.nlm.nih.gov/pubmed/22253615 http://dx.doi.org/10.1155/2012/696215

Ejemplares similares

Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions
por: Naudí, Alba, et al.
Publicado: (2013)

Membrane lipid unsaturation as physiological adaptation to animal longevity
por: Naudí, Alba, et al.
Publicado: (2013)

Plasma long-chain free fatty acids predict mammalian longevity
por: Jové, Mariona, et al.
Publicado: (2013)

Plant-Derived Phenolics Inhibit the Accrual of Structurally Characterised Protein and Lipid Oxidative Modifications
por: Soler-Cantero, Arantza, et al.
Publicado: (2012)

The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer’s Disease Pathology
por: Jové, Mariona, et al.
Publicado: (2021)

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice
por: Jové, Mariona, et al.
Publicado: (2014)

When cholesterol is not cholesterol: a note on the enzymatic determination of its concentration in model systems containing vegetable extracts
por: Jové, Mariona, et al.
Publicado: (2010)

Target of rapamycin activation predicts lifespan in fruit flies
por: Scialò, Filippo, et al.
Publicado: (2015)

Antioxidants Halt Axonal Degeneration in a Mouse Model of X-Adrenoleukodystrophy
por: López-Erauskin, Jone, et al.
Publicado: (2011)

Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome
por: Jové, Mariona, et al.
Publicado: (2017)

Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex
por: Cabré, Rosanna, et al.
Publicado: (2016)

A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma
por: Servià, Luis, et al.
Publicado: (2019)

Plasma antioxidant capacity in critical polytraumatized patients?: methods, severity, and anatomic location
por: Serviá, Luis, et al.
Publicado: (2014)

Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS
por: Cacabelos, Daniel, et al.
Publicado: (2016)

Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity
por: Mota-Martorell, Natalia, et al.
Publicado: (2020)

Ether Lipid-Mediated Antioxidant Defense in Alzheimer’s Disease
por: Jové, Mariona, et al.
Publicado: (2023)

Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
por: Jové, Mariona, et al.
Publicado: (2023)

Differential metabolic profiles associated to movement behaviour of stream-resident brown trout (Salmo trutta)
por: Oromi, Neus, et al.
Publicado: (2017)

Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance
por: Fourcade, Stéphane, et al.
Publicado: (2017)

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity
por: Mota-Martorell, Natalia, et al.
Publicado: (2020)

Cell senescence, loss of splicing, and lipid metabolism in TDP-43-related neurodegenerative processes
por: Torres, Pascual, et al.
Publicado: (2023)

Location-dependent effects of trauma on oxidative stress in humans
por: Servia, Luis, et al.
Publicado: (2018)

Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism
por: Jové, Mariona, et al.
Publicado: (2016)

Adipose Tissue Mitochondrial Factors Profile after Dietary Bioactive Compound Weight Reduction Treatments in a Mice Obesity Model
por: Cassanye, Anna, et al.
Publicado: (2019)

Effects of Aging and Methionine Restriction on Rat Kidney Metabolome
por: Pradas, Irene, et al.
Publicado: (2019)

Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women
por: Pradas, Irene, et al.
Publicado: (2019)

Lipid alterations in human frontal cortex in ALS‐FTLD‐TDP43 proteinopathy spectrum are partly related to peroxisome impairment
por: Andrés‐Benito, Pol, et al.
Publicado: (2021)

The Advanced Lipoxidation End-Product Malondialdehyde-Lysine in Aging and Longevity
por: Jové, Mariona, et al.
Publicado: (2020)

mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
por: Mota-Martorell, Natalia, et al.
Publicado: (2022)

Metabolomics Predicts Neuroimaging Characteristics of Transient Ischemic Attack Patients()
por: Purroy, Francisco, et al.
Publicado: (2016)

Lipidomics Reveals a Tissue-Specific Fingerprint
por: Pradas, Irene, et al.
Publicado: (2018)

Succination of Protein Thiols in Human Brain Aging
por: Jové, Mariona, et al.
Publicado: (2020)

Tumour-microenvironmental blood flow determines a metabolomic signature identifying lysophospholipids and resolvin D as biomarkers in endometrial cancer patients
por: Eritja, Núria, et al.
Publicado: (2017)

Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility
por: Serrano, Jose C. E., et al.
Publicado: (2016)

Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients
por: Gonzalo, Hugo, et al.
Publicado: (2019)

Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target
por: Jové, Mariona, et al.
Publicado: (2018)

Selective brain regional changes in lipid profile with human aging
por: Mota-Martorell, Natalia, et al.
Publicado: (2022)

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity
por: Gómez, Alexia, et al.
Publicado: (2014)

Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age
por: Jové, Mariona, et al.
Publicado: (2021)

Aberrant regulation of the GSK‐3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy
por: Ranea‐Robles, Pablo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_v3f4m1ca59t1blp9n7t8dmnu7q