Cargando…
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
Genomic instability is a common feature of cancer etiology. This provides an avenue for therapeutic intervention, since cancer cells are more susceptible than normal cells to DNA damaging agents. However, there is growing evidence that the epigenetic mechanisms that impact DNA methylation and histon...
Autores principales: | Rajendran, Praveen, Ho, Emily, Williams, David E, Dashwood, Roderick H |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255482/ https://www.ncbi.nlm.nih.gov/pubmed/22247744 http://dx.doi.org/10.1186/1868-7083-3-4 |
Ejemplares similares
-
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates
por: Rajendran, Praveen, et al.
Publicado: (2013) -
BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells
por: Kapoor, Sabeeta, et al.
Publicado: (2022) -
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
por: Rajendran, Praveen, et al.
Publicado: (2011) -
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon
por: Rajendran, Praveen, et al.
Publicado: (2015) -
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
por: Zhang, Shilan, et al.
Publicado: (2023)