CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations

The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only surv...

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Autores principales: Seok, Yoonmi, Kim, Juwon, Choi, Jong Rak, Kim, Yu Ri, Park, Seo-Jin, Kim, Sue Jung, Song, Jaewoo, Lee, Kyung-A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Laboratory Medicine 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255497/
https://www.ncbi.nlm.nih.gov/pubmed/22259787
http://dx.doi.org/10.3343/alm.2012.32.1.95
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author Seok, Yoonmi
Kim, Juwon
Choi, Jong Rak
Kim, Yu Ri
Park, Seo-Jin
Kim, Sue Jung
Song, Jaewoo
Lee, Kyung-A
author_facet Seok, Yoonmi
Kim, Juwon
Choi, Jong Rak
Kim, Yu Ri
Park, Seo-Jin
Kim, Sue Jung
Song, Jaewoo
Lee, Kyung-A
author_sort Seok, Yoonmi
collection PubMed
description The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
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spelling pubmed-32554972012-01-18 CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations Seok, Yoonmi Kim, Juwon Choi, Jong Rak Kim, Yu Ri Park, Seo-Jin Kim, Sue Jung Song, Jaewoo Lee, Kyung-A Ann Lab Med Case Report The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations. The Korean Society for Laboratory Medicine 2012-01 2011-12-20 /pmc/articles/PMC3255497/ /pubmed/22259787 http://dx.doi.org/10.3343/alm.2012.32.1.95 Text en © The Korean Society for Laboratory Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Seok, Yoonmi
Kim, Juwon
Choi, Jong Rak
Kim, Yu Ri
Park, Seo-Jin
Kim, Sue Jung
Song, Jaewoo
Lee, Kyung-A
CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
title CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
title_full CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
title_fullStr CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
title_full_unstemmed CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
title_short CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
title_sort cd5-negative blastoid variant mantle cell lymphoma with complex ccnd1/igh and myc aberrations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255497/
https://www.ncbi.nlm.nih.gov/pubmed/22259787
http://dx.doi.org/10.3343/alm.2012.32.1.95
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