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Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins

We have recently reported the possible imatinib-resistant mechanism; long-term exposure of leukemia cells to imatinib downregulated levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) via hypermethylation of its promoter region (Leukemia 2010; 24: 1631). The present study explor...

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Detalles Bibliográficos
Autores principales:	Nishioka, C, Ikezoe, T, Yang, J, Udaka, K, Yokoyama, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255508/ https://www.ncbi.nlm.nih.gov/pubmed/22829096 http://dx.doi.org/10.1038/bcj.2011.33

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