The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium

Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. Our previous work identified a previously unknown effect of VPA in reducing phosphoinositide production in the simple model Dictyostelium followed by the transfer of data to a...

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Detalles Bibliográficos
Autores principales: Chang, Pishan, Orabi, Benoit, Deranieh, Rania M., Dham, Manik, Hoeller, Oliver, Shimshoni, Jakob A., Yagen, Boris, Bialer, Meir, Greenberg, Miriam L., Walker, Matthew C., Williams, Robin S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255550/
https://www.ncbi.nlm.nih.gov/pubmed/21876211
http://dx.doi.org/10.1242/dmm.008029

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