Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain

Impaired neuronal migration and cell death are commonly observed in patients with peroxisomal biogenesis disorders (PBDs), and in mouse models of this diseases. In Pex11β-deficient mice, we observed that the deletion of a single allele of the Pex11β gene (Pex11β(+/−) heterozygous mice) caused cell d...

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Detalles Bibliográficos
Autores principales: Ahlemeyer, Barbara, Gottwald, Magdalena, Baumgart-Vogt, Eveline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255551/
https://www.ncbi.nlm.nih.gov/pubmed/21954064
http://dx.doi.org/10.1242/dmm.007708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255551/
https://www.ncbi.nlm.nih.gov/pubmed/21954064
http://dx.doi.org/10.1242/dmm.007708

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